Giorgio Giardina

Pubblicazioni

Titolo Pubblicato in Anno
Beyond the barrier: the immune-inspired pathways of tumor extravasation CELL COMMUNICATION AND SIGNALING 2024
Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study SCIENTIFIC REPORTS 2023
A conserved scaffold with heterogeneous metal ion binding site: the multifaceted example of HD-GYP proteins COORDINATION CHEMISTRY REVIEWS 2022
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex THE FEBS JOURNAL 2022
Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase PROTEIN SCIENCE 2022
Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex 2022
Folding Mechanism and Aggregation Propensity of the KH0 Domain of FMRP and Its R138Q Pathological Variant INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Editorial: Tailored Modulation of Interactions Between Biomolecules: Fundamentals and Applications FRONTIERS IN MOLECULAR BIOSCIENCES 2022
Studying ggdef domain in the act: Minimize conformational frustration to prevent artefacts LIFE 2021
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021
Importance of amino acids in brain parenchyma invasion by cancer cells ONCOSCIENCE 2021
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 16th SIBBM Seminar Frontiers in Molecular Biology Frontiers in metabolic research Abstracts 2021
Signal transduction and c-di-GMP second messenger: novel tools to investigare the mechanism of nutrient sensing. WEBPRO - Proteins on the Web 2021. 2021
L- Arginine in Pseudomonas aeruginosa controls c-di-GMP levels and biofilm formation efb 2021 2021
Structural clues of Serine hidroxymethyltransferase (SHMT) riboregulation 2nd Italian Crystallographic Association Biological MacroMolecules Group Meeting 2021
The emerging role of amino acids of the brain microenvironment in the process of metastasis formation CANCERS 2021
Crystal structure of Aspergillus fumigatus AroH, an aromatic amino acid aminotransferase PROTEINS 2021
Metformin is a pyridoxal-5′-phosphate (PLP)-competitive inhibitor of SHMT2 CANCERS 2021
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity CELL DEATH & DISEASE 2020
Structure and function of HD-GYP phosphodiesterases Microbial Cyclic Di-Nucleotide Signaling 2020

ERC

  • LS1
  • LS1_1
  • LS1_2
  • LS1_8

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I started my academic career in organic synthesis and moved to Structural Biology in 2003, acquiring my PhD in 2006 in the Dep. of Biochemical Sciences. Since then I solved many protein structures using X-ray crystallography and have been mainly involved in the structure/function study of:

  • Human PLP dependent enzyme such as Serine hydroxymethyltransferase (SHMT), Dopa decarboxylase (DDC) and Alanine:glyoxylate amino trasferase (AGT) all involved in severe pathologies and/or cancer
  • Proteins from Pseudomonas aeruginosa involved in the regulation of biofilm formation or/and the denitrification pathway

As many others in the field I am now making the first steps in cryo-EM.

Finally, I’m also a freelance artist, specialized in: Cover Art; Web-Graphic Design; 3D modelling/animation and Scientific illustration (visit my website: giorgio-giardina.com)

Keywords

structural biology
PLP
PLP-dependent enzymes
protein conformational changes
x-ray crystallography
protein complex
Comunicazione scientifica
divulgazione scientifica

Progetti di Ricerca

Gruppi di ricerca

RNA-mediated modulation of cell metabolism

Gruppi di ricerca - Responsabile

Laboratorio di biochimica e analisi strutturale

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