Ricerc@Sapienza

We are extending our previous observations on the Impact of vaccination on NK cell compartment. Our study revealed that mRNA based Sars-Cov2 vaccine stably affect NK cell phenotype and functions highlighting the impact of genetic and environmental host-related factors in modulating NK cell susceptibility to post-vaccinal Fc-dependen

Studio dei meccanismi molecolari che regolano sviluppo e funzione delle cellule T. Signaling di NOTCH nello sviluppo e nella progressione della leucemia linfoblastica acuta di tipo T (T-ALL). Ruolo del recettore chemochinico CXCR4 nella diffusione della T-ALL. Meccanismi mediati dai microRNA nella progressione della T-ALL. Uso di inibitori di NOTCH e BH3 mimetici per contrastare la patologia.

PARylation, a post-translational modification catalyzed by PARP-1, represents a central mechanism connecting oxidative stress, inflammation, and epigenetic regulation of gene expression.

Aging and endocrine-metabolic diseases are complex conditions characterized by profound epigenetic alterations that affect gene expression and cellular function. Epigenetic mechanisms, such as DNA methylation and hydroxymethylation, play a central role in the adaptation of cells to environmental and metabolic stimuli.

Liquid biopsy is a non-invasive sampling alternative, which overcomes the challenges associated with tumor tissue biopsies and allows a real-time monitoring of cancer disease. We are focused on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients .

The reciprocal interplay between the circadian clock machinery and hypothalamus-pituitary-adrenal axis has been largely demonstrated: the circadian clock may control the physiological circadian endogenous glucocorticoid (GC) secretion and action; GCs, in turn, are potent regulators of the circadian clock and their inappropriate replacement has been associated with metabolic and immune impairment.

The research group aim to study cellular, molecular and functional aspects of the adipose tissue/endocrine system homeostasis/biology with particular focus on interplay with the immune system.

Due to sensorimotor dysfunctions, falls are frequent and dire in older type 2 diabetes patients (T2D). Susceptibility to falls results from multiple interacting and environmental factors. Three common microvascular complications of diabetes, peripheral neuropathy, retinopathy and vestibulopathy, are established contributors to increased postural sway and falls. Hypoglycemia itself can also cause falls in these patients.

People with autoimmune diabetes (AD) are at higher risk of death due to the development of its acute and long-term sequelae. The process towards a cure for AD should encompass the identification of new pathways to prevent beta-cell failure and complications. A deep knowledge of AD heterogeneity is essential to understand and tackle the processes leading to disease onset and progression.