Alessandro Paiardini | Ricerc@Sapienza

Publications

Title	Published on	Year
Unraveling the Engagement of Kinases to CRBN Through a Shared Structural Motif to Optimize PROTACs Efficacy	BIOMOLECULES	2025
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase	PROTEIN SCIENCE	2024
Making Use of Averaging Methods in MODELLER for Protein Structure Prediction	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2024
Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions	FRONTIERS IN IMMUNOLOGY	2024
AlPaCas: allele-specific CRISPR gene editing through a protospacer-adjacent-motif (PAM) approach	NUCLEIC ACIDS RESEARCH	2024
STRUCTURE-BASED MECHANISM OF RIBOREGULATION OF THE METABOLIC ENZYME SHMT1	MOLECULAR CELL	2024
The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target	THE FEBS JOURNAL	2024
An inherited TBX3 alteration in a prenatal case of ulnar‐mammary syndrome: Clinical assessment and functional characterization in Drosophila melanogaster	JOURNAL OF CELLULAR PHYSIOLOGY	2024
An outlook on structural biology after AlphaFold: tools, limits and perspectives	FEBS OPEN BIO	2024
Off-target inhibition of human dihydroorotate dehydrogenase (hDHODH) highlights challenges in the development of fat mass and obesity-associated protein (FTO) inhibitors	ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE	2024
A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression	CANCER GENE THERAPY	2023
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation	LIFE SCIENCE ALLIANCE	2023
Revisiting degron motifs in human AURKA required for its targeting by APC/CFZR1	LIFE SCIENCE ALLIANCE	2023
Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds	SCIENTIFIC REPORTS	2023
Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF	MICROBIOLOGY SPECTRUM	2023
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells	FRONTIERS IN IMMUNOLOGY	2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8	JOURNAL OF MEDICINAL CHEMISTRY	2023
When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri	SCIENTIFIC REPORTS	2023
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.	MICROBIOLOGICAL RESEARCH	2023

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KET

Big data & computing
Life-science technologies & biotechnologies

Interessi di ricerca

Progetti di Ricerca

MODULATING THE MITOTIC KINASE FUNCTION OF AURORA-A WITH PROTEIN-PROTEIN INTERACTION INHIBITORS

Gruppi di ricerca

Nutrient sensing and redox transducers in bacterial biofilm.