Ricerc@Sapienza

PURPOSE: The aim of this study was to validate the role of MR/Ultrasound Fusion-Guided Targeted Biopsy as a first diagnostic modality in subjects with clinical suspicion of prostate cancer (PCa). MATERIALS AND METHODS: 108 men (age range 46-78 years) with clinical suspicion for PCa (PSA > 4 ng/mL) underwent multiparametric MRI of the prostate (mpMRI) and, when suspicious lesion were found (according to the PIRADSv2 scoring system), targeted biopsy was performed. All patients without significant alteration patterns at mpMRI have been referred for follow-up at 1 year.

Objectives: To evaluate accuracy and inter-observer variability using Vesical Imaging-Reporting and Data System (VI-RADS) for discrimination between non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Methods: Between September 2017 and July 2018, 78 patients referred for suspected bladder cancer underwent multiparametric MRI of the bladder (mpMRI) prior to transurethral resection of bladder tumor (TURBT). All mpMRI were reviewed by two radiologists, who scored each lesion according to VI-RADS.

A Brain–Computer Interface (BCI) uses measurements of the voluntary brain activity for driving a communication system; it requires the activation of mental tasks. In the last few years, a new paradigm of activation has been used, consisting in the autonomous brain activation through self-induced emotions, remembered on autobiographical basis. In the present paper, such paradigm is implemented and the resulting BCI system is described, from the classification strategy to the graphic user interface necessary for synchronising mental tasks and collecting EEG signals derived by emotions.

Graph theory analysis on resting state electroencephalographic rhythms disclosed topological properties of cerebral network. In Alzheimer’s disease (AD) patients, this approach showed mixed results. Granger causality matrices were used as input to the graph theory allowing to estimate the strength and the direction of information transfer between electrode pairs.

AIM:
To investigate the correlation between conventional computed tomography (CT) features, quantitative texture analysis (QTA), epidermal growth factor receptor (EGFR) mutations, and survival rates in patients with lung adenocarcinoma.
MATERIALS AND METHODS:

PURPOSE:
The aim of the present study was to evaluate the impact of the aortic bifurcation (AB) morphological characteristics, analyzed on computed tomography angiography (CTA), on outcomes of patients with abdominal aortic aneurysms (AAAs), treated by endovascular aneurysm repair (EVAR) in a single-center experience.

PURPOSE:
Leptin (LEP) is a peptide hormone with multiple physiological functions. Besides its systemic actions, it has important peripheral roles such as a mitogen action on keratinocytes following skin lesions. We previously showed that LEP mRNA is significantly induced in response to neutron irradiation in mouse skin and that the protein increases in the irradiated epidermis and in the related subcutaneous adipose tissue. In this work, we investigated the post-transcriptional regulation of LEP by miRNAs and the conservation of LEP's role in radiation response in human cells.

Through-the-wall radar imaging (TWRI) systems allow police, fire personnel, and defense forces to detect, identify, and track subjects inside buildings or under rubble. In this paper, the delay and sum (DAS) and range migration (RM) algorithms are compared as imaging techniques for a multiple input multiple output (MIMO) stepped-frequency (SF) radar system. These algorithms have been applied to analytical, simulated, and measured data both in the absence and in the presence of a wall between the antenna and the target.

The recent developments of medical applications of electromagnetic fields in both diagnostic and therapeutic scenarios has posed the attention on the accurate knowledge of the dielectric properties of human tissues. Accordingly, several studies were recently devoted to the measurements of such properties under various physiological conditions. Since biological tissues show a high variability, to compare the different data it is necessary to thoroughly control the experimental conditions.

Multidisciplinary study of a 7000 years old naturally mummified body from SW Libya reveals different pathologies.