Risultati ricerca pubblicazioni

Evolving trend in the management of heterozygous familial hypercholesterolemia in Italy: a retrospective, single center, observational study

pubblicato su: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES - 2020

D'Erasmo L., Commodari D., Di Costanzo A., Minicocci I., Polito L., Ceci F., Montali A., Maranghi M., Arca M.

Real word outcomes associated with use of raltegravir in older people living with HIV: results from the 60 months follow-up of the RAL-age cohort

pubblicato su: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY - 2020

Santinelli Letizia, Ceccarelli Giancarlo, Borrazzo Cristian, Celani Luigi, Pavone Paolo, Innocenti Giuseppe Pietro, Spagnolello Ornella, Fimiani Caterina, Ceci Fabrizio, Di Sora Fiorella, Mezzaroma Ivano, Maria Mastroianni &, Claudio, D'Ettorre Gabriella

Spectrum of mutations and long-term clinical outcomes in genetic chylomicronemia syndromes

pubblicato su: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 2019

D'Erasmo Laura, DI COSTANZO Alessia, Cassandra Francesca, Minicocci Ilenia, Polito Luca, Montali Anna, Ceci Fabrizio, Arca Marcello

Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis

pubblicato su: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES - 2018

Loffredo L., Baratta F., Ludovica P., Battaglia S., Carnevale R., Nocella C., Novo M., Pannitteri G., Ceci F., Angelico F., Violi F., Del Ben M.

Severity of OSAS, CPAP and cardiovascular events: a follow-up study

pubblicato su: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION - 2018

Baratta Francesco, Pastori Daniele, Fabiani Mario, Fabiani Valerio, Ceci Fabrizio, Lillo Rossella, Lolli Valeria, Brunori Marco, Pannitteri Gaetano, Cravotto Elena, De Vito Corrado, Angelico Francesco, Del Ben Maria

HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease

pubblicato su: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE - 2020

ROMEO Maria Anele, Gilardini Montani M. S., Gaeta A., D'Orazi G., Faggioni A., Cirone M.

Interplay between endoplasmic reticulum (ER) stress and autophagy induces mutant p53H273 degradation

pubblicato su: BIOMOLECULES - 2020

Garufi Alessia, Federici Giulia, Gilardini Montani Maria Saveria, Crispini Alessandra, Cirone Mara, D'Orazi Gabriella

PBA preferentially impairs cell survival of glioblastomas carrying mutp53 by reducing its expression level, stabilizing wtp53, downregulating the mevalonate kinase and dysregulating UPR

pubblicato su: BIOMOLECULES - 2020

Romeo M. A., Gilardini Montani M. S., Benedetti R., Garufi A., D'Orazi G., Cirone M.

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression

pubblicato su: BRITISH JOURNAL OF CANCER - 2020

Gilardini Montani M. S., Falcinelli L., Santarelli R., Granato M., Romeo M. A., Cecere N., Gonnella R., D'Orazi G., Faggioni A., Cirone M.

Perturbation of bulk and selective macroautophagy, abnormal UPR activation and their interplay pave the way to immune dysfunction, cancerogenesis and neurodegeneration in ageing

pubblicato su: AGEING RESEARCH REVIEWS - 2020

Cirone M.

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

pubblicato su: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH - 2020

Garufi Alessia, Baldari Silvia, Pettinari Riccardo, Gilardini Montani Maria Saveria, D'Orazi Valerio, Pistritto Giuseppa, Crispini Alessandra, Giorno Eugenia, Toietta Gabriele, Marchetti Fabio, Cirone Mara, D'Orazi Gabriella

KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis

pubblicato su: INTERNATIONAL JOURNAL OF CANCER - 2020

Santarelli Roberta, Arteni Ana Maria Brindusa, Gilardini Montani Maria Saveria, Romeo Maria Anele, Gaeta Aurelia, Gonnella Roberta, Faggioni Alberto, Cirone Mara

EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation

pubblicato su: AUTOPHAGY - 2019

Gilardini Montani Maria Saveria, Santarelli R, Granato M, Gonnella R, Torrisi Mr, Faggioni A, Cirone M.

Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress

pubblicato su: JOURNAL OF GENERAL VIROLOGY - 2019

Romeo Maria Anele, Masuelli Laura, Gaeta Aurelia, Nazzari Cristina, Granato Marisa, GILARDINI MONTANI MARIA SAVERIA, Faggioni Alberto, Cirone Mara

Stat3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation

pubblicato su: VIROLOGY - 2019

Santarelli R, Carillo V, Romeo Ma, Gaeta A, Nazzari C, Gonnella R, Granato M, D'Orazi G, Faggioni A, Cirone M

Mutant p53 and cellular stress pathways: a criminal alliance that promotes cancer progression

pubblicato su: CANCERS - 2019

D'Orazi G, Cirone M

Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?

pubblicato su: NEURAL REGENERATION RESEARCH - 2019

Romeo Ma, Faggioni A, Cirone M

Mutant p53, stabilized by its interplay with HSP90, activates a positive feed-back loop between NRF2 and p62 that induces chemio-resistance to Apigenin in pancreatic cancer cells

pubblicato su: CANCERS - 2019

Gilardini Montani Ms, Cecere N, Granato M, Romeo Ma, Falcinelli L, Ciciarelli U, D'Orazi G, Faggioni A, Cirone M

Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response

pubblicato su: ONCOTARGET - 2019

Garufi Alessia, Traversi Gianandrea, Montani Maria Saveria Gilardini, D'Orazi Valerio, Pistritto Giuseppa, Cirone Mara, D'Orazi Gabriella

Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and

pubblicato su: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY - 2019

Gilardini Montani M. S., Falcinelli L., Santarelli R., Romeo M. A., Granato M., Faggioni A., Cirone M.

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

pubblicato su: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH - 2019

Cirone M., Gilardini Montani M. S., Granato M., Garufi A., Faggioni A., D'Orazi G.

HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells

pubblicato su: VIRUS RESEARCH - 2019

Romeo M. A., Gilardini Montani M. S., Falcinelli L., Gaeta A., Nazzari C., Faggioni A., Cirone M.

Quercetin interrupts the positive feedback loop between STAT3 and IL-6, promotes autophagy, and reduces ROS, preventing EBV-driven B cell immortalization

pubblicato su: BIOMOLECULES - 2019

Granato M., Gilardini Montani M. S., Zompetta C., Santarelli R., Gonnella R., Romeo M. A., D'orazi G., Faggioni A., Cirone M.

Sourcing the immune system to induce immunogenic cell death in Kras-colorectal cancer cells

pubblicato su: BRITISH JOURNAL OF CANCER - 2019

Cirone M., Lotti L. V., Granato M., Renzo L. D., Biunno I., Cattaneo M., Verginelli F., Vespa S., Davies D., Wells V., Mariani-Costantini R., Mallucci L.

EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3

pubblicato su: JOURNAL OF LEUKOCYTE BIOLOGY - 2018

Gilardini Montani Maria Saveria, Santarelli Roberta, Falcinelli Luca, Gonnella Roberta, Granato Marisa, Di Renzo Livia, Cuomo Laura, Vitillo Marina, Faggioni Alberto, Cirone Mara

Cytotoxic drugs activate KSHV lytic cycle in latently infected PEL cells by inducing a moderate ROS increase controlled by HSF1, NRF2 and p62/SQSTM1

pubblicato su: VIRUSES - 2018

GRANATO Marisa, GILARDINI MONTANI MARIA SAVERIA, Angiolillo Camilla, D’Orazi Gabriella, FAGGIONI Alberto, CIRONE Mara

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis

pubblicato su: VIRUSES - 2018

Cirone Mara

Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer

pubblicato su: FRONTIERS IN ONCOLOGY - 2020

Belardinilli Francesca, Capalbo Carlo, Malapelle Umberto, Pisapia Pasquale, Raimondo Domenico, Milanetti Edoardo, Mahdavian Yasaman, Liccardi Carlotta, Paci Paola, Sibilio Pasquale, Pepe Francesco, Bonfiglio Caterina, Mezi Silvia, Magri Valentina, Coppa Anna, Nicolussi Arianna, Gradilone Angela, Petroni Marialaura, Di Giulio Stefano, Fabretti Francesca, Infante Paola, Coni Sonia, Canettieri Gianluca, Troncone Giancarlo, Giannini Giuseppe

A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer

pubblicato su: CANCERS - 2019

Capalbo Carlo, Belardinilli Francesca, Raimondo Domenico, Milanetti Edoardo, Malapelle Umberto, Pisapia Pasquale, Magri Valentina, Prete Alessandra, Pecorari Silvia, Colella Mariarosaria, Coppa Anna, Bonfiglio Caterina, Nicolussi Arianna, Valentini Virginia, Tessitore Alessandra, Cardinali Beatrice, Petroni Marialaura, Infante Paola, Santoni Matteo, Filetti Marco, Colicchia Valeria, Paci Paola, Mezi Silvia, Longo Flavia, Cortesi Enrico, Marchetti Paolo, Troncone Giancarlo, Bellavia Diana, Canettieri Gianluca, Giannini Giuseppe

Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer

pubblicato su: PEERJ - 2019

Nicolussi Arianna, Belardinilli Francesca, Mahdavian Yasaman, Colicchia Valeria, D'Inzeo Sonia, Petroni Marialaura, Zani Massimo, Ferraro Sergio, Valentini Virginia, Ottini Laura, Giannini Giuseppe, Capalbo Carlo, Coppa Anna

Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk

pubblicato su: ENDOCRINE CONNECTIONS - 2019

Rizzolo Piera, Silvestri Valentina, Valentini Virginia, Zelli Veronica, Bucalo Agostino, Zanna Ines, Bianchi Simonetta, Tibiletti Maria Grazia, Russo Antonio, Varesco Liliana, Tedaldi Gianluca, Bonanni Bernardo, Azzollini Jacopo, Manoukian Siranoush, Coppa Anna, Giannini Giuseppe, Cortesi Laura, Viel Alessandra, Montagna Marco, Peterlongo Paolo, Radice Paolo, Palli Domenico, Ottini Laura, Giannini Giuseppe

SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

pubblicato su: SCIENTIFIC REPORTS - 2019

Petroni Marialaura, Sahùn Roncero Maria, Ramponi Valentina, Fabretti Francesca, Nicolis Di Robilant Vittoria, Moretti Marta, Alfano Vincenzo, Corsi Alessandro, De Panfilis Simone, Giubettini Maria, Di Giulio Stefano, Capalbo Carlo, Belardinilli Francesca, Coppa Anna, Sardina Francesca, Colicchia Valeria, Pedretti Flaminia, Infante Paola, Cardinali Beatrice, Tessitore Alessandra, Canettieri Gianluca, De Smaele Enrico, Giannini Giuseppe

Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data

pubblicato su: PEERJ - 2019

Nicolussi Arianna, Belardinilli Francesca, Silvestri Valentina, Mahdavian Yasaman, Valentini Virginia, D'Inzeo Sonia, Petroni Marialaura, Zani Massimo, Ferraro Sergio, Di Giulio Stefano, Fabretti Francesca, Fratini Beatrice, Gradilone Angela, Ottini Laura, Giannini Giuseppe, Coppa Anna, Capalbo Carlo

A possible role of FANCM mutations in male breast cancer susceptibility: Results from a multicenter study in Italy

pubblicato su: THE BREAST - 2018

Silvestri Valentina, Rizzolo Piera, Zelli Veronica, Valentini Virginia, Zanna Ines, Bianchi Simonetta, Tibiletti Maria Grazia, Varesco Liliana, Russo Antonio, Tommasi Stefania, Coppa Anna, Capalbo Carlo, Calistri Daniele, Viel Alessandra, Cortesi Laura, Manoukian Siranoush, Bonanni Bernardo, Montagna Marco, Palli Domenico, Radice Paolo, Peterlongo Paolo, Ottini Laura

Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition

pubblicato su: MOLECULAR AND CLINICAL ONCOLOGY - 2018

Capalbo Carlo, Belardinilli Francesca, Filetti Marco, Parisi Claudia, Petroni Marialaura, Colicchia Valeria, Tessitore Alessandra, Santoni Matteo, Coppa Anna, Giannini Giuseppe, Marchetti Paolo

Coexistence of three EGFR mutations in an NSCLC patient: A brief report

pubblicato su: THE INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS - 2018

Belardinilli Francesca, Gradilone Angela, Gelibter Alain, Zani Massimo, Occhipinti Mario, Ferraro Sergio, Nicolazzo Chiara, Coppa Anna, Giannini Giuseppe

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

pubblicato su: CELL DEATH & DISEASE - 2018

Petroni Marialaura, Sardina Francesca, Infante Paola, Bartolazzi Armando, Locatelli Erica, Fabretti Francesca, Di Giulio Stefano, Capalbo Carlo, Cardinali Beatrice, Coppa Anna, Tessitore Alessandra, Colicchia Valeria, Sahùn Roncero Maria, Belardinilli Francesca, Di Marcotullio Lucia, Soddu Silvia, Comes Franchini Mauro, Petricci Elena, Gulino Alberto, Giannini Giuseppe

Contribution of MUTYH variants to male breast cancer risk: results from a multicenter study in Italy

pubblicato su: FRONTIERS IN ONCOLOGY - 2018

Rizzolo Piera, Silvestri Valentina, Bucalo Agostino, Zelli Veronica, Valentini Virginia, Catucci Irene, Zanna Ines, Masala Giovanna, Bianchi Simonetta, Spinelli Alessandro Mauro, Tommasi Stefania, Tibiletti Maria Grazia, Russo Antonio, Varesco Liliana, Coppa Anna, Calistri Daniele, Cortesi Laura, Viel Alessandra, Bonanni Bernardo, Azzollini Jacopo, Manoukian Siranoush, Montagna Marco, Radice Paolo, Palli Domenico, Peterlongo Paolo, Ottini Laura

Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module

pubblicato su: CELL REPORTS - 2020

Di Magno L., Manni S., Di Pastena F., Coni S., Macone A., Cairoli S., Sambucci M., Infante P., Moretti M., Petroni M., Nicoletti C., Capalbo C., De Smaele E., Di Marcotullio L., Giannini G., Battistini L., Goffredo B. M., Iorio E., Agostinelli E., Maroder M., Canettieri G.

From single gene analysis to single cell profiling: a new era for precision medicine

pubblicato su: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH - 2020

Di Martino Maria Teresa, Meschini Stefania, Scotlandi Katia, Riganti Chiara, De Smaele Enrico, Zazzeroni Francesca, Donadelli Massimo, Leonetti Carlo, Caraglia Michele

Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription

pubblicato su: NUCLEIC ACIDS RESEARCH - 2020

Sorino Cristina, Catena Valeria, Bruno Tiziana, De Nicola Francesca, Scalera Stefano, Bossi Gianluca, Fabretti Francesca, Mano Miguel, De Smaele Enrico, Fanciulli Maurizio, Iezzi Simona

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

pubblicato su: INTERNATIONAL JOURNAL OF ONCOLOGY - 2019

Antonucci Laura, Di Magno Laura, D'Amico Davide, Manni Simona, Serrao Silvia Maria, Di Pastena Fiorella, Bordone Rosa, Yurtsever Zuleyha Nihan, Caimano Miriam, Petroni Marialaura, Giorgi Alessandra, Schininà Maria Eugenia, Yates Iii John R, Di Marcotullio Lucia, De Smaele Enrico, Checquolo Saula, Capalbo Carlo, Agostinelli Enzo, Maroder Marella, Coni Sonia, Canettieri Gianluca

EZH2, JMJD3 and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells

pubblicato su: CELL DEATH & DISEASE - 2019

Pediconi Natalia, Lupacchini Leonardo, Salerno Debora, Angrisani Annapaola, Peruzzi Giovanna, DE SMAELE Enrico, Levrero Massimo, Belloni Laura

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

pubblicato su: NATURE COMMUNICATIONS - 2019

Bufalieri F., Infante P., Bernardi F., Caimano M., Romania P., Moretti M., Lospinoso Severini L., Talbot J., Melaiu O., Tanori M., Di Magno L., Bellavia D., Capalbo C., Puget S., De Smaele E., Canettieri G., Guardavaccaro D., Busino L., Peschiaroli Angelo, Pazzaglia S., Giannini G., Melino G., Locatelli F., Gulino A., Ayrault O., Fruci D., Di Marcotullio L.

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

pubblicato su: ONCOGENESIS - 2019

Spiombi Eleonora, Angrisani Annapaola, Fonte Simone, De Feudis Giuseppina, Fabretti Francesca, Cucchi Danilo, Izzo Mariapaola, Infante Paola, Miele Evelina, Po Agnese, Di Magno Laura, Magliozzi Roberto, Guardavaccaro Daniele, Maroder Marella, Canettieri Gianluca, Giannini Giuseppe, Ferretti Elisabetta, Gulino Alberto, Di Marcotullio Lucia, Moretti Marta, De Smaele Enrico

The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway

pubblicato su: CELL DEATH & DISEASE - 2019

Scicchitano S., Giordano M., Lucchino V., Montalcini Y., Chiarella E., Aloisio A., Codispoti B., Zoppoli P., Melocchi V., Bianchi F., De Smaele E., Mesuraca M., Morrone G., Bond H. M.

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

pubblicato su: NATURE COMMUNICATIONS - 2018

Infante Paola, Faedda Roberta, Bernardi Flavia, Bufalieri Francesca, Lospinoso Severini Ludovica, Alfonsi Romina, Mazzà Daniela, Siler Mariangela, Coni Sonia, Po Agnese, Petroni Marialaura, Ferretti Elisabetta, Mori Mattia, De Smaele Enrico, Canettieri Gianluca, Capalbo Carlo, Maroder Marella, Screpanti Isabella, Kool Marcel, Pfister Stefan M., Guardavaccaro Daniele, Gulino Alberto, Di Marcotullio Lucia