Antonio Musaro'

Pubblicazioni

Titolo Pubblicato in Anno
The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart ELIFE 2023
Rejuvenating muscle stem cells with the glutathione system CELL METABOLISM 2023
Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia SCIENTIFIC REPORTS 2023
Modelling three-dimensional cancer-associated cachexia and therapy: the molecular basis and therapeutic potential of interleukin-6 transignalling blockade JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE 2023
Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1 AGING CELL 2023
Wheel Running Adversely Affects Disease Onset and Neuromuscular Interplay in Amyotrophic Lateral Sclerosis Slow Progression Mouse Model CURRENT NEUROVASCULAR RESEARCH 2023
Sympathetic neuropathology is revealed in muscles affected by amyotrophic lateral sclerosis FRONTIERS IN PHYSIOLOGY 2023
Repurposing of trimetazidine for amyotrophic lateral sclerosis: a study in SOD1G93A mice BRITISH JOURNAL OF PHARMACOLOGY 2022
Development of a novel technique for the measurement of neuromuscular junction functionality in isotonic conditions CELLULAR AND MOLECULAR BIOENGINEERING 2022
The development of an innovative embedded sensor for the optical measurement of ex-vivo engineered muscle tissue contractility SENSORS 2022
Effects of ROI positioning on the measurement of engineered muscle tissue contractility with an optical tracking method 2022 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2022 - Conference Proceedings 2022
The hormetic and hermetic role of IL-6 AGEING RESEARCH REVIEWS 2022
A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients CELL DEATH DISCOVERY 2021
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle BIOMATERIALS 2021
Fenretinide beneficial effects on amyotrophic lateral sclerosis-associated SOD1G93A mutant protein toxicity: in vitro and In vivo evidences NEUROSCIENCE 2021
Circulating myomiRs in muscle denervation: from surgical to ALS pathological condition CELLS 2021
Sustained systemic levels of IL-6 impinge early muscle growth and induce muscle atrophy and wasting in adulthood CELLS 2021
Hyaluronan-cholesterol nanogels for the enhancement of the ocular delivery of therapeutics PHARMACEUTICS 2021
Measuring and modelling nonlinear elasticity of ex vivo mouse muscles JOURNAL OF HEALTHCARE ENGINEERING 2021
Optimal force evaluation for isotonic fatigue characterization in mouse Tibialis Anterior muscle IEEE Medical Measurements and Applications, MeMeA 2020 - Conference Proceedings 2020

ERC

  • LS3_1
  • LS3_12
  • LS3_13
  • LS3_14

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

The general aim of our projects involves the characterization of cellular, molecular and functional aspects of muscle homeostasis and regeneration.

Specifically, our research focuses in three areas:

(1) Define the signals from the niche to improve muscle regeneration.

Muscle tissue possesses a stem cell compartment; nevertheless it is not clear why it fails to regenerate under pathological conditions. Either the resident stem cells are too rare or intrinsically incapable of repairing major damage, or perhaps the injured/pathological tissue is a prohibitive environment for stem cell activation and function. Our project aims to address this critical issue in sarcopenic muscle and different muscle diseases.

(2) The physiopathologic interplay between muscle and nerve.

The effective connection between muscle and nerve is crucial to the capacity of both partners to survive and function adequately throughout life. A crucial system severely affected in several neuromuscular diseases is the loss of effective connection between muscle and nerve, leading to a pathological non-communication between the two tissues.  One of the best examples of impaired interplay between the nerve and muscle is observed in ALS. ALS is a disorder involving degeneration of motor neurons, muscle atrophy and paralysis. Whereas the steps leading to the pathological state are well characterized, several fundamental issues are still controversial: are the motor neurons the first and only targets of ALS? What is the contribution of muscle, if any, to the pathogenesis of ALS? These questions raised from the following considerations: i) ALS is a disease of genetic origin in which the contribution of cells and tissues other than neuronal cannot been excluded; ii) skeletal muscle, always considered just a target of the disease, is a relatively unexamined tissue that potentially directly contributes to ALS. Thus, analyzing the retrograde-talk muscle-to-nerve could be extremely important to determine if and to what degree muscle plays a role in the progression of the pathology and to develop alternative therapeutic approaches. 

(3) Muscle engineered in vitro model to study muscle homeostasis and differentiation

In our laboratory it has been recently developed a 3-dimensional skeletal muscle construct, called eX-vivo Muscle engineered Tissue (X-MET), which mimics the complex morphological properties of skeletal muscle tissue and it represents  an ideal in vitro model of skeletal muscle, simplifying the study of complex processes such as muscle homeostasis and response to drug treatment,  under physiologic and pathologic conditions.

Keywords

Adult stem cells
3D skeletal muscle models
NMJ
cardiac regeneration

Gruppi di ricerca

Gruppi di ricerca - Responsabile

Laboratori di ricerca

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