Bruno Botta


Titolo Pubblicato in Anno
Chalcones and chalcone-mimetic derivatives as Notch inhibitors in a model of T-cell Acute Lymphoblastic Leukemia ACS MEDICINAL CHEMISTRY LETTERS 2019
IR ion spectroscopy in a combined approach with MS/MS and IM-MS to discriminate epimeric anthocyanin glycosides (cyanidin 3-O-glucoside and -galactoside) INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 2019
Nigritanine as a new potential antimicrobial alkaloid for the treatment of staphylococcus aureus-induced infections TOXINS 2019
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth CANCERS 2019
Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma CELL COMMUNICATION AND SIGNALING 2019
In Memory of Maurizio Botta: his Contribution to the Development of Computer-Aided Drug Design JOURNAL OF CHEMICAL INFORMATION AND MODELING 2019
Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies COMPTES RENDUS CHIMIE 2019
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2018
Naturally occurring diels-alder-type adducts from morus nigra as potent inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 ddiabetes patients: Rescue by alpha-ketoglutarate and TET-TDG functional reactivation CIRCULATION RESEARCH 2018
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer PHARMACOLOGICAL RESEARCH 2018
A multi-methodological approach in the study of Italian PDO “Cornetto di Pontecorvo” red sweet pepper FOOD CHEMISTRY 2018
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2018
Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction ORGANIC CHEMISTRY FRONTIERS 2018
A high-throughput screening of a chemical compound library in ovarian cancer stem cells COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 2018
Design, palladium-catalyzed synthesis, and biological investigation of 2-substituted 3-aroylquinolin-4(1H)-ones as inhibitors of the Hedgehog signaling pathway. JOURNAL OF MEDICINAL CHEMISTRY 2017
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro NANOMEDICINE 2017


  • LS4_12
  • PE5
  • PE5_16
  • PE5_17


  • Nanotecnologie
  • Life-science technologies & biotechnologies
  • Sustainable technologies & development

Interessi di ricerca

Isolamento, caratterizzazione di prodotti naturali da piante. Semisintesi e sintesi totale di prodotti naturali. Sintesi di macrocicli resorc[4]arenici e applicazioni. Funzionalizzazione di nanotubi di carbonio con macrocicli per applicazioni di biosensoristica. Chimica dei cannabinoidi e prodotti estratti dalla Cannabis.


organic chemistry
prodotti naturali
Multiwalled carbon nanotubes (MWCNTs)

Gruppi di ricerca - Responsabile

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