Bruno Botta | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2019
1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma	CELL COMMUNICATION AND SIGNALING	2019
In Memory of Maurizio Botta: his Contribution to the Development of Computer-Aided Drug Design	JOURNAL OF CHEMICAL INFORMATION AND MODELING	2019
Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies	COMPTES RENDUS CHIMIE	2019
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2018
Naturally occurring diels-alder-type adducts from morus nigra as potent inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 ddiabetes patients: Rescue by alpha-ketoglutarate and TET-TDG functional reactivation	CIRCULATION RESEARCH	2018
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer	PHARMACOLOGICAL RESEARCH	2018
A multi-methodological approach in the study of Italian PDO “Cornetto di Pontecorvo” red sweet pepper	FOOD CHEMISTRY	2018
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2018
Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction	ORGANIC CHEMISTRY FRONTIERS	2018
A high-throughput screening of a chemical compound library in ovarian cancer stem cells	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING	2018
Design, palladium-catalyzed synthesis, and biological investigation of 2-substituted 3-aroylquinolin-4(1H)-ones as inhibitors of the Hedgehog signaling pathway.	JOURNAL OF MEDICINAL CHEMISTRY	2017
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2017
Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro	NANOMEDICINE	2017
Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia	SCIENTIFIC REPORTS	2017
Green routes for the production of enantiopure benzylisoquinoline alkaloids	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2017
Natural modulators of nonalcoholic fatty liver disease: mode of action analysis and in silico ADME-Tox prediction	TOXICOLOGY AND APPLIED PHARMACOLOGY	2017

ERC

LS4_12
PE5
PE5_16
PE5_17

KET

Nanotecnologie
Life-science technologies & biotechnologies
Sustainable technologies & development

Interessi di ricerca

Isolamento, caratterizzazione di prodotti naturali da piante. Semisintesi e sintesi totale di prodotti naturali. Sintesi di macrocicli resorc[4]arenici e applicazioni. Funzionalizzazione di nanotubi di carbonio con macrocicli per applicazioni di biosensoristica. Chimica dei cannabinoidi e prodotti estratti dalla Cannabis.

Keywords

chimica

BASI BIOLOGICHE DEL CANCRO

organic chemistry

prodotti naturali

Multiwalled carbon nanotubes (MWCNTs)

biosensing

calixarene

Resorc[4]arene