Bruno Botta


Titolo Pubblicato in Anno
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype CELL DEATH & DISEASE 2016
Total Synthesis of (±)-Kuwanol E JOURNAL OF NATURAL PRODUCTS 2016
Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry Calixarenes and Beyond 2016
The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro CHEMICO-BIOLOGICAL INTERACTIONS 2016
Mycobacterium tuberculosis-secreted tyrosine phosphatases as targets against tuberculosis: exploring natural sources in searching for new drugs CURRENT PHARMACEUTICAL DESIGN 2016
Histone demethylating agents as potential S-adenosyl-l-methionine-competitors MEDCHEMCOMM 2016
Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach ORGANIC & BIOMOLECULAR CHEMISTRY 2015
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors EMBO JOURNAL 2015
Kuwanon-L as a new allosteric HIV-1 integrase inhibitor: molecular modeling and biological evaluation CHEMBIOCHEM 2015
Exploring oxidovanadium(IV) complexes as YopH inhibitors: mechanism of action and modeling studies ACS MEDICINAL CHEMISTRY LETTERS 2015
Targeting GLI factors to inhibit the Hedgehog pathway TRENDS IN PHARMACOLOGICAL SCIENCES 2015
Click reaction as a tool to combine pharmacophores: The case of Vismodegib CHEMPLUSCHEM 2015


  • LS4_12
  • PE5
  • PE5_16
  • PE5_17


  • Nanotecnologie
  • Life-science technologies & biotechnologies
  • Sustainable technologies & development

Interessi di ricerca

Isolamento, caratterizzazione di prodotti naturali da piante. Semisintesi e sintesi totale di prodotti naturali. Sintesi di macrocicli resorc[4]arenici e applicazioni. Funzionalizzazione di nanotubi di carbonio con macrocicli per applicazioni di biosensoristica. Chimica dei cannabinoidi e prodotti estratti dalla Cannabis.


organic chemistry
prodotti naturali
Multiwalled carbon nanotubes (MWCNTs)

Gruppi di ricerca - Responsabile

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