Bruno Botta | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype	CELL DEATH & DISEASE	2016
Total Synthesis of (±)-Kuwanol E	JOURNAL OF NATURAL PRODUCTS	2016
Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry	Calixarenes and Beyond	2016
The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro	CHEMICO-BIOLOGICAL INTERACTIONS	2016
Mycobacterium tuberculosis-secreted tyrosine phosphatases as targets against tuberculosis: exploring natural sources in searching for new drugs	CURRENT PHARMACEUTICAL DESIGN	2016
Histone demethylating agents as potential S-adenosyl-l-methionine-competitors	MEDCHEMCOMM	2016
Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach	ORGANIC & BIOMOLECULAR CHEMISTRY	2015
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors	EMBO JOURNAL	2015
Kuwanon-L as a new allosteric HIV-1 integrase inhibitor: molecular modeling and biological evaluation	CHEMBIOCHEM	2015
Exploring oxidovanadium(IV) complexes as YopH inhibitors: mechanism of action and modeling studies	ACS MEDICINAL CHEMISTRY LETTERS	2015
Targeting GLI factors to inhibit the Hedgehog pathway	TRENDS IN PHARMACOLOGICAL SCIENCES	2015
Click reaction as a tool to combine pharmacophores: The case of Vismodegib	CHEMPLUSCHEM	2015

ERC

LS4_12
PE5
PE5_16
PE5_17

KET

Nanotecnologie
Life-science technologies & biotechnologies
Sustainable technologies & development

Interessi di ricerca

Isolamento, caratterizzazione di prodotti naturali da piante. Semisintesi e sintesi totale di prodotti naturali. Sintesi di macrocicli resorc[4]arenici e applicazioni. Funzionalizzazione di nanotubi di carbonio con macrocicli per applicazioni di biosensoristica. Chimica dei cannabinoidi e prodotti estratti dalla Cannabis.

Keywords

chimica

BASI BIOLOGICHE DEL CANCRO

organic chemistry

prodotti naturali

Multiwalled carbon nanotubes (MWCNTs)

biosensing

calixarene

Resorc[4]arene

Gruppi di ricerca - Responsabile

Botta Lab