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romano.silvestri@uniroma1.it
Romano Silvestri
Professore Ordinario
Struttura:
DIPARTIMENTO DI CHIMICA E TECNOLOGIE DEL FARMACO
E-mail:
romano.silvestri@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
BIOLOGY DIRECT
2021
Discovery of a novel class of norovirus inhibitors with high barrier of resistance
PHARMACEUTICALS
2021
Emerging therapeutic agents for colorectal cancer
MOLECULES
2021
A METHOD TO MEASURE THE BARRIER EFFECT OF DRUGS AND ITS APPLICATION IN THE STUDY OF HYDROLYZED COLLAGEN
AGRO FOOD INDUSTRY HI-TECH
2021
Selenotriapine - an isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
ARABIAN JOURNAL OF CHEMISTRY
2020
Design, synthesis and discovery of novel N,N'-carbazoyl-aryl-urea inhibitors of Zika NS5 methyltransferase and virus replication.
CHEMMEDCHEM
2020
Discovery of new 1,1'-biphenyl-4-sulfonamides as selective subnanomolar human carbonic anhydrase II inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
2020
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2020
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage
ACS MEDICINAL CHEMISTRY LETTERS
2020
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2020
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc
CHEMMEDCHEM
2020
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites
SCIENTIFIC REPORTS
2020
Targeting the interaction between the SH3 domain of Grb2 and Gab2
CELLS
2020
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53
NEURO-ONCOLOGY
2020
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents
ACS MEDICINAL CHEMISTRY LETTERS
2019
Towards modern anticancer agents that interact with tubulin
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2019
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin
BIOCHEMICAL PHARMACOLOGY
2019
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b
MOLECULES
2019
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2019
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Progetti di Ricerca
Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment
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