Romano Silvestri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Design, synthesis and discovery of novel N,N'-carbazoyl-aryl-urea inhibitors of Zika NS5 methyltransferase and virus replication.	CHEMMEDCHEM	2020
Discovery of new 1,1'-biphenyl-4-sulfonamides as selective subnanomolar human carbonic anhydrase II inhibitors	ACS MEDICINAL CHEMISTRY LETTERS	2020
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2020
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage	ACS MEDICINAL CHEMISTRY LETTERS	2020
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2020
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics	JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN	2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc	CHEMMEDCHEM	2020
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites	SCIENTIFIC REPORTS	2020
Targeting the interaction between the SH3 domain of Grb2 and Gab2	CELLS	2020
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53	NEURO-ONCOLOGY	2020
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents	ACS MEDICINAL CHEMISTRY LETTERS	2019
Towards modern anticancer agents that interact with tubulin	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES	2019
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin	BIOCHEMICAL PHARMACOLOGY	2019
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b	MOLECULES	2019
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2019
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress	CARDIOVASCULAR RESEARCH	2019
Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity	LETTERS IN DRUG DESIGN & DISCOVERY	2018
Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells	ACS CHEMICAL NEUROSCIENCE	2018
A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist	BIOCHEMISTRY	2018
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy	ONCOGENE	2018

Progetti di Ricerca

Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment