Romano Silvestri


Titolo Pubblicato in Anno
Design, synthesis and discovery of novel N,N'-carbazoyl-aryl-urea inhibitors of Zika NS5 methyltransferase and virus replication. CHEMMEDCHEM 2020
Discovery of new 1,1'-biphenyl-4-sulfonamides as selective subnanomolar human carbonic anhydrase II inhibitors ACS MEDICINAL CHEMISTRY LETTERS 2020
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage ACS MEDICINAL CHEMISTRY LETTERS 2020
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc CHEMMEDCHEM 2020
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites SCIENTIFIC REPORTS 2020
Targeting the interaction between the SH3 domain of Grb2 and Gab2 CELLS 2020
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53 NEURO-ONCOLOGY 2020
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents ACS MEDICINAL CHEMISTRY LETTERS 2019
Towards modern anticancer agents that interact with tubulin EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2019
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin BIOCHEMICAL PHARMACOLOGY 2019
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b MOLECULES 2019
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress CARDIOVASCULAR RESEARCH 2019
Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity LETTERS IN DRUG DESIGN & DISCOVERY 2018
Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells ACS CHEMICAL NEUROSCIENCE 2018
A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist BIOCHEMISTRY 2018
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy ONCOGENE 2018

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