Romano Silvestri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors	JOURNAL OF MEDICINAL CHEMISTRY	2015
Endogenous vs exogenous allosteric modulators in GPCRs: a dispute for shuttling CB1 among different membrane microenvironments	SCIENTIFIC REPORTS	2015
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer	JOURNAL OF MEDICINAL CHEMISTRY	2015
Poster: "In vivo selection of JARID histone demethylases inhibitors and their use to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation”	Abstracts of the 27th International Conference on Yeast Genetics and Molecular Biology	2015
New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer	SIMCC2015	2015
Synthesis of New Indoles with Potent Tubulin Polymerization Inhibiting Activity Including Hedgehog-Dependent Cancer and Enhanced Stimulation of NK Cell Cytotoxic Activity	Abstract eBook	2015
New Pyrazolecarboxamides a s Anti-HCV Agents via Targeting Cyclooxygenase-2	Abstract eBook	2015
Drug Design and Synthesis of New Indolylarylsulfones as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors	Abstract eBook	2015
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses	VIROLOGY JOURNAL	2015
Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells	CANCER BIOLOGY & THERAPY	2015
Distinct temporal fingerprint for cyclic adenosine monophosphate (cAMP) signaling of Indole-2-carboxamides as allosteric modulators of the cannabinoid receptors	JOURNAL OF MEDICINAL CHEMISTRY	2015
New frontiers in selective human MAO-B inhibitors	JOURNAL OF MEDICINAL CHEMISTRY	2015

Progetti di Ricerca

Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment