Romano Silvestri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors	ANTIVIRAL CHEMISTRY & CHEMOTHERAPY	2018
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects	BRITISH JOURNAL OF CLINICAL PHARMACOLOGY	2018
Treating chronic myeloid leukemia by inhibition of tubulin polymerization	Book of abstracts	2018
Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication	JOURNAL OF MEDICINAL CHEMISTRY	2018
A high-throughput screening of a chemical compound library in ovarian cancer stem cells	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING	2018
Indolylarylsulfones as novel potent anti-HIV-1 agents	Book of abstract	2018
p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells	ONCOIMMUNOLOGY	2017
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules	ONCOTARGET	2017
Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells	BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE	2017
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin	ACS MEDICINAL CHEMISTRY LETTERS	2017
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
N-Pyrrylarylsulfones with high therapeutic potential	MOLECULES	2017
Chiral indolylarylsulfone non-nucleoside reverse transcriptase inhibitors as new potent and broad spectrum anti-HIV-1 agents	JOURNAL OF MEDICINAL CHEMISTRY	2017
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
Computer-aided identification and lead optimization of dual murine double minute 2 and 4 binders: structure-activity relationship studies and pharmacological activity	JOURNAL OF MEDICINAL CHEMISTRY	2017
Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2017
Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo	TUMOR BIOLOGY	2016
VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2016
Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines	MEDCHEMCOMM	2016

Progetti di Ricerca

Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment