Romano Silvestri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53	NEURO-ONCOLOGY	2020
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents	ACS MEDICINAL CHEMISTRY LETTERS	2019
Towards modern anticancer agents that interact with tubulin	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES	2019
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin	BIOCHEMICAL PHARMACOLOGY	2019
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b	MOLECULES	2019
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2019
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress	CARDIOVASCULAR RESEARCH	2019
Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity	LETTERS IN DRUG DESIGN & DISCOVERY	2018
Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells	ACS CHEMICAL NEUROSCIENCE	2018
A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist	BIOCHEMISTRY	2018
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy	ONCOGENE	2018
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors	ANTIVIRAL CHEMISTRY & CHEMOTHERAPY	2018
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects	BRITISH JOURNAL OF CLINICAL PHARMACOLOGY	2018
Treating chronic myeloid leukemia by inhibition of tubulin polymerization	Book of Abstracts	2018
Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication	JOURNAL OF MEDICINAL CHEMISTRY	2018
A high-throughput screening of a chemical compound library in ovarian cancer stem cells	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING	2018
Indolylarylsulfones as novel potent anti-HIV-1 agents	Book of Abstract	2018
p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells	ONCOIMMUNOLOGY	2017
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules	ONCOTARGET	2017

Progetti di Ricerca

Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment