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romano.silvestri@uniroma1.it
Romano Silvestri
Professore Ordinario
Struttura:
DIPARTIMENTO DI CHIMICA E TECNOLOGIE DEL FARMACO
E-mail:
romano.silvestri@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection
CIRCULATION RESEARCH
2023
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2023
A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations
MOLECULES
2023
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators
BIOORGANIC CHEMISTRY
2023
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
2023
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor
CANCERS
2022
Single-run chemo- and enantio-selective high-performance liquid chromatography separation of tramadol and its principal metabolite, O-desmethyltramadol, using a chlorinated immobilized amylose-based chiral stationary phase under multimodal elution conditions
SEPARATION SCIENCE PLUS
2022
Modulating undruggable targets to overcome cancer therapy resistance
DRUG RESISTANCE UPDATES
2022
Exploring CCRL2 chemerin binding using accelerated molecular dynamics
PROTEINS
2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2022
EFFICACY AND SAFETY OF A NOVEL FOOD SUPPLEMENT IN THE TREATMENT OF FUNCTIONAL DYSPEPSIA: A PILOT OPEN STUDY
AGRO FOOD INDUSTRY HI-TECH
2022
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
2022
Emerging Direct Targeting β-Catenin Agents
MOLECULES
2022
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2021
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme
EUROPEAN JOURNAL OF PHARMACOLOGY
2021
RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway
EUROPEAN JOURNAL OF PHARMACOLOGY
2021
RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2021
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
BIOLOGY DIRECT
2021
Discovery of a novel class of norovirus inhibitors with high barrier of resistance
PHARMACEUTICALS
2021
Emerging therapeutic agents for colorectal cancer
MOLECULES
2021
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Progetti di Ricerca
Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment
Laboratori di ricerca
Drug Design and Synthesis Center (DDSC)
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