Romano Silvestri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection	CIRCULATION RESEARCH	2023
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2023
A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations	MOLECULES	2023
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators	BIOORGANIC CHEMISTRY	2023
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent	ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE	2023
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor	CANCERS	2022
Single-run chemo- and enantio-selective high-performance liquid chromatography separation of tramadol and its principal metabolite, O-desmethyltramadol, using a chlorinated immobilized amylose-based chiral stationary phase under multimodal elution conditions	SEPARATION SCIENCE PLUS	2022
Modulating undruggable targets to overcome cancer therapy resistance	DRUG RESISTANCE UPDATES	2022
Exploring CCRL2 chemerin binding using accelerated molecular dynamics	PROTEINS	2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2022
EFFICACY AND SAFETY OF A NOVEL FOOD SUPPLEMENT IN THE TREATMENT OF FUNCTIONAL DYSPEPSIA: A PILOT OPEN STUDY	AGRO FOOD INDUSTRY HI-TECH	2022
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor	JOURNAL OF MEDICINAL CHEMISTRY	2022
Emerging Direct Targeting β-Catenin Agents	MOLECULES	2022
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2021
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme	EUROPEAN JOURNAL OF PHARMACOLOGY	2021
RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway	EUROPEAN JOURNAL OF PHARMACOLOGY	2021
RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES	2021
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer	BIOLOGY DIRECT	2021
Discovery of a novel class of norovirus inhibitors with high barrier of resistance	PHARMACEUTICALS	2021
Emerging therapeutic agents for colorectal cancer	MOLECULES	2021

Progetti di Ricerca

Design, synthesis and biological evaluation of tubulin binding agents as anticancer hybrid compounds
New 3-Aroyl-1,4-diarylpyrroles as Inhibitors of Cancer Cells and Chronic Myeloid Leukaemia Cells through Interaction with Tubulin
Tubulin as target in chronic myeloid leukemia treatment

Laboratori di ricerca

Drug Design and Synthesis Center (DDSC)