Ricerc@Sapienza

I started my academic career in organic synthesis and moved to Structural Biology in 2003, acquiring my PhD in 2006 in the Dep. of Biochemical Sciences. Since then I solved many protein structures using X-ray crystallography and have been mainly involved in the structure/function study of:

• Human PLP dependent enzyme such as Serine hydroxymethyltransferase (SHMT), Dopa decarboxylase (DDC) and Alanine:glyoxylate amino trasferase (AGT) all involved in severe pathologies and/or cancer
• Proteins from Pseudomonas aeruginosa involved in the regulation of biofilm formation or/and the denitrification pathway

As many others in the field I am now making the first steps in cryo-EM.

Finally, I’m also a freelance artist, specialized in: Cover Art; Web-Graphic Design; 3D modelling/animation and Scientific illustration (visit my website: giorgio-giardina.com)