Pubblicazioni

Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities

2024 - NEUROPHARMACOLOGY

Carpi, M.; Palagini, L.; Fernandes, M.; Calvello, C.; Geoffroy, P. A.; Miniati, M.; Pini, S.; Gemignani, A.; Mercuri, N. B.; Liguori, C.

Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome

2023 - NEUROPHARMACOLOGY

Urbinati, Chiara; Lanzillotta, Chiara; Cosentino, Livia; Valenti, Daniela; Quattrini, Maria Cristina; Di Crescenzo, Livia; Prestia, Francesca; Pietraforte, Donatella; Perluigi, Marzia; Di Domenico, Fabio; Vacca, Rosa Anna; De Filippis, Bianca

GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders

2023 - NEUROPHARMACOLOGY

Nicoletti, Ferdinando; DI MENNA, Luisa; Iacovelli, Luisa; Orlando, Rosamaria; Zuena, Anna Rita; Jeffrey Conn, P.; Dogra, Shalini; Joffe, Max E.

Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism

2023 - NEUROPHARMACOLOGY

Di Menna, Luisa; Orlando, Rosamaria; D'Errico, Giovanna; Ginerete, Roxana Paula; Machaczka, Agata; Bonaccorso, Carmela Maria; Arena, Andrea; Spatuzza, Michela; Celli, Roberta; Alborghetti, Marika; Ciocca, Eleonora; Zuena, Anna Rita; Scioli, Mariarosaria; Bruno, Valeria; Battaglia, Giuseppe; Nicoletti, Ferdinando; Catania, Maria Vincenza

The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia

2022 - NEUROPHARMACOLOGY

Brown, Jessica; Iacovelli, Luisa; Di Cicco, Gabriele; Grayson, Ben; Rimmer, Lauren; Fletcher, Jennifer; C Neill, Joanna; J Wall, Mark; T Ngomba, Richard; Harte, Michael

MicroRNA-34a regulates 5-HT2C expression in dorsal raphe and contributes to the anti-depressant-like effect of fluoxetine

2021 - NEUROPHARMACOLOGY

Lo Iacono, L.; Ielpo, D.; Parisi, C.; Napoli, G.; Accoto, A.; Di Segni, M.; Babicola, L.; D'Addario, S. L.; Guzzo, S. M.; Pascucci, T.; Ventura, R.; Andolina, D.

Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice

2021 - NEUROPHARMACOLOGY

Busceti, C. L.; Ginerete, R. P.; Di Menna, L.; D'Errico, G.; Cisani, F.; Di Pietro, P.; Imbriglio, T.; Bruno, V.; Battaglia, G.; Fornai, F.; Monn, J. A.; Pittaluga, A.; Nicoletti, F.

Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.

2021 - NEUROPHARMACOLOGY

Di Cicco, Gabriele; Marzano, Emanuela; Iacovelli, Luisa; Celli, Roberta; van Luijtelaar, Gilles; Nicoletti, Ferdinando; T Ngomba, Richard; J Wall, Mark

Xlr4 as a new candidate gene underlying vulnerability to cocaine effects

2020 - NEUROPHARMACOLOGY

Di Segni, M.; D'Addario, S. L.; Babicola, L.; Ielpo, D.; Lo Iacono, L.; Andolina, D.; Accoto, A.; Luchetti, A.; Mancini, C.; Parisi, C.; D'Onofrio, M.; Arisi, I.; Brandi, R.; Pascucci, T.; Cifani, C.; D'Amato, F. R.; Ventura, R.

Future avenues for Alzheimer's disease detection and therapy: Liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery

2020 - NEUROPHARMACOLOGY

Harald, Hampel; Andrea, Vergallo; Filippo, Caraci; A Claudio, Cuello; Pablo, Lemercier; Bruno, Vellas; Kelly Virecoulon, Giudici; Filippo, Baldacci; Britta, HÃ¤nisch; Marion, Haberkamp; Karl, Broich; NisticÃ², Robert; Enzo, Emanuele; Francisco, Llavero; JosÃ© L, Zugaza; Alejandro, LucÃa; Ezio, Giacobini; Simone, Lista; Babiloni, Claudio

Effects of intranasally-delivered pro-nerve growth factors on the septohippocampal system in healthy and diabetic rat

2020 - NEUROPHARMACOLOGY

Soligo, Marzia; Protto, Virginia; Chiaretti, Antonio; Piccinin, Sonia; De Stefano, Maria Egle; NisticÃ², Robert; Bracci-Laudieroa, Luisa; Manni, Luigi

Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission

2020 - NEUROPHARMACOLOGY

Celli, Roberta; Wall, Mark J.; Santolini, Ines; Vergassola, Matteo; Di Menna, Luisa; Mascio, Giada; Cannella, Milena; van Luijtelaar, Gilles; Pittaluga, Anna; Ciruela, Francisco; Bruno, Valeria Maria Gloria; Nicoletti, Ferdinando; Ngomba, Richard T.

Oxytocin in the neural control of eating: at the crossroad between homeostatic and non-homeostatic signals

2020 - NEUROPHARMACOLOGY

Romano, A.; Friuli, M.; Cifani, C.; Gaetani, S.

The active heroin metabolite 6-acetylmorphine has robust reinforcing effects as assessed by self-administration in the rat

2019 - NEUROPHARMACOLOGY

Avvisati, Riccardo; Bogen, Inger Lise; Andersen, Jannike M; Vindenes, Vigdis; MÃ¸rland, JÃ¸rg; Badiani, Aldo; Boix, Fernando

Methyl-CpG binding protein 2 functional alterations provide vulnerability to develop behavioral and molecular features of post-traumatic stress disorder in male mice

2019 - NEUROPHARMACOLOGY

Cosentino, Livia; Vigli, Daniele; Medici, Vanessa; Flor, Herta; Lucarelli, Marco; Fuso, Andrea; De Filippis, Bianca

The prokineticin receptor antagonist PC1 rescues memory impairment induced by Î² amyloid administration through the modulation of prokineticin system

2019 - NEUROPHARMACOLOGY

Maftei, D.; Ratano, P.; Fusco, I.; Marconi, V.; Squillace, S.; Negri, L.; Severini, C.; Balboni, G.; Steardo, L.; Bronzuoli, M. R.; Scuderi, C.; Campolongo, P.; Lattanzi, R.

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

2018 - NEUROPHARMACOLOGY

Di Menna, Luisa; Joffe, Max E.; Iacovelli, Luisa; Orlando, Rosamaria; Lindsley, Craig W.; Mairesse, JÃ¨rome; GressÃ¨ns, Pierre; Cannella, Milena; Caraci, Filippo; Copani, Agata; Bruno, Valeria; Battaglia, Giuseppe; Conn, P. Jeffrey; Nicoletti, Ferdinando

Pharmacological inhibiton of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation

2018 - NEUROPHARMACOLOGY

Ratano, Patrizia; Petrella, Carla; Forti, Fabrizio; Passeri, Pamela Petrocchi; Morena, Maria; Palmery, Maura; Trezza, Viviana; Severini, Cinzia; Campolongo, Patrizia

Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide

2018 - NEUROPHARMACOLOGY

Costa, Alessia; Cristiano, Claudia; Cassano, Tommaso; Gallelli, Cristina Anna; Gaetani, Silvana; Ghelardini, Carla; Blandina, Patrizio; Calignano, Antonio; Passani, M. Beatrice; Provensi, Gustavo

The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

2018 - NEUROPHARMACOLOGY

Morley-Fletcher, S.; Zuena, A. R.; Mairesse, J.; Gatta, E.; Van Camp, G.; Bouwalerh, H.; Riozzi, B.; Battaglia, G.; Pittaluga, A.; Olivero, G.; Mocaer, E.; Bretin, S.; Nicoletti, F.; Maccari, S.

Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome

2018 - NEUROPHARMACOLOGY

Vigli, D.; Cosentino, L.; Raggi, C.; Laviola, G.; Woolley-Roberts, M.; De, Filippis

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder

2018 - NEUROPHARMACOLOGY

Vigli, D.; Rusconi, L.; Valenti, D.; La, Montanara; Cosentino, L.; Lacivita, E.; Leopoldo, M.; Amendola, E.; Gross, C.; Landsberger, N.; Laviola, G.; Kilstrup-Nielsen, C.; Vacca, R. A.; De Filippis, B.

Ricerc@Sapienza

Pubblicazioni

Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities

Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome

GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders

Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism

The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia

MicroRNA-34a regulates 5-HT2C expression in dorsal raphe and contributes to the anti-depressant-like effect of fluoxetine

Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice

Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.

Xlr4 as a new candidate gene underlying vulnerability to cocaine effects

Future avenues for Alzheimer's disease detection and therapy: Liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery

Effects of intranasally-delivered pro-nerve growth factors on the septohippocampal system in healthy and diabetic rat

Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission

Oxytocin in the neural control of eating: at the crossroad between homeostatic and non-homeostatic signals

The active heroin metabolite 6-acetylmorphine has robust reinforcing effects as assessed by self-administration in the rat

Methyl-CpG binding protein 2 functional alterations provide vulnerability to develop behavioral and molecular features of post-traumatic stress disorder in male mice

The prokineticin receptor antagonist PC1 rescues memory impairment induced by Î² amyloid administration through the modulation of prokineticin system

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Pharmacological inhibiton of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation

Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide

The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder

Effects of pre-reproductive maternal enrichment on maternal care, offspring's play behavior and oxytocinergic neurons

Sensitivity to cocaine in adult mice is due to interplay between genetic makeup, early environment and later experience

Metabotropic glutamate receptors, 5 years on