Ricerc@Sapienza

The group is interested in i) analyzing the genetic and epigenetic mechanisms that regulate hepatocyte differentiation and transdifferentiation (EMT) and contribute to the progression of hepatocellular carcinoma, ii) dissecting the signaling pathways that mediate cellular responses to microenvironmental stimuli (such as soluble factors and extracellular matrix stiffness) under phys

https://sites.google.com/uniroma1.it/labottini

SIMU2DRIVE - BML Website:

coming soon

Notch signaling pathway is deeply involved in T-cell development and differentiation and, consequently, its dysregulation influences the onset and progression of different diseases, including T-cell leukemia and autoimmune diabetes.

The NanoDelivery Lab is focused on the comprehensive study of the Protein Corona.

My research highlights how distinct biological contexts—viruses and tumors—converge in their immune evasion strategies, exploiting mechanisms such as dsRNA editing by ADAR1, suppression of type I interferon responses, and modulation of NK cell activity to escape elimination by the innate immunity system.

RESEARCH

Our laboratory focuses on understanding how alterations in calcium homeostasis, cell-cycle regulation, and stress response pathways affect epidermal physiology and carcinogenesis. We aim to uncover the molecular mechanisms underlying impaired cell adhesion, differentiation, and DNA damage response in skin pathologies and cancer, with the goal of identifying novel therapeutic strategies.

Main topics of our lab include:

1) Molecular mechanisms of Hailey-Hailey Disease (HHD)