Ricerc@Sapienza

The mission of the research group is to improve cancer precision prevention and treatment by providing a comprehensive characterization of the genetic susceptibility and molecular pathology of solid tumors using “omics” data in the frame of national and international collaborations.

SIMU2DRIVE - BML Website:

coming soon

Notch signaling pathway is deeply involved in T-cell development and differentiation and, consequently, its dysregulation influences the onset and progression of different diseases, including T-cell leukemia and autoimmune diabetes.

The NanoDelivery Lab is focused on the comprehensive study of the Protein Corona.

My research highlights how distinct biological contexts—viruses and tumors—converge in their immune evasion strategies, exploiting mechanisms such as dsRNA editing by ADAR1, suppression of type I interferon responses, and modulation of NK cell activity to escape elimination by the innate immunity system.

RESEARCH

Our laboratory focuses on understanding how alterations in calcium homeostasis, cell-cycle regulation, and stress response pathways affect epidermal physiology and carcinogenesis. We aim to uncover the molecular mechanisms underlying impaired cell adhesion, differentiation, and DNA damage response in skin pathologies and cancer, with the goal of identifying novel therapeutic strategies.

Main topics of our lab include:

1) Molecular mechanisms of Hailey-Hailey Disease (HHD)

Alterations in Notch signaling play a crucial role in cancer development and progression. Depending on the cancer context, Notch signaling can act as either an oncogene or a tumor suppressor. Understanding the mechanisms underlying this dual role is essential for identifying novel molecular targets and developing innovative therapeutic strategies.