Alterations in Notch signaling play a crucial role in cancer development and progression. Depending on the cancer context, Notch signaling can act as either an oncogene or a tumor suppressor. Understanding the mechanisms underlying this dual role is essential for identifying novel molecular targets and developing innovative therapeutic strategies.

My research focuses on understanding how the immune system detects and controls cancer cells, particularly in the context of cellular senescence and stress responses. By investigating the molecular mechanisms that regulate immune surveillance, we aim to identify new strategies to enhance immune recognition and clearance of cancer cells.

Current Funding

• Exploring the potential of ADAR1 as a new immunotherapeutic target in cervical cancer
  (AIRC Project IG 2021 – ID 25680)

Di Marcotullio Lab website: 

sites.google.com/uniroma1.it/dimarcotulliolab/home

CMGU - GG Lab website: 

https://sites.google.com/uniroma1.it/giannini-lab/home

RNA-binding proteins (RBPs) play multiple roles in RNA metabolism and their mutation, delocalization and/or altered expression have been proposed to cause familial and sporadic amyotrophic latrla sclerosis (ALS). In our lab, human iPSC-derived motor neurons, skeletal muscle cells and neuromuscular organoids are used as in vitro model systems to study the role of the RBPs FUS, HuD/ELAVL4 and TDP-43 in ALS. To this aim, we have developed protocols for rapid and efficient conversion of human iPSCs into motor neurons and skeletal muscle cells.

Measuring operators’ cognitive and emotional states, training progresses, and teamwork is really innovative, especially in operative and real contexts. The Neuroscience Lab develops methodologies able to measure humans' mental states like mental workload, stress, attention, fatigue in real time.

Prof. Fimia carries out his research actiivity at the “Cell Stress Biology” laboratory of Department of Molecular Medicine, as well as at the Cell Biology and Electron Microscopy lab of the National Institute for Infectious Diseases (INMI) L. Spallanzani in Rome,
where the Prof. Fimia has part of his research group to carry out research activity on the basis of a formal Collaborative Agreement. 

Lab website: https://sites.google.com/uniroma1.it/emculab-canettieri

Our laboratory is interested in understanding how epigenetic and metabolic reprogramming influence tumor behaviour and to invetigate the possibility to target these alterations for therapeutic purposes.

The current main topics of our lab are:

1) Energy and redox rewiring in Cancer

Prof. Carmine Mancone is the director of the Tumor Microenvironment Research Group. This group works on understanding the molecular basis of the interaction between cancer cells and the tumor microenvironment (TME) in liver and biliary tract carcinomas.