Progetti di ricerca
| Titolo del progetto | Anno | Proponente | Abstract | ERC | Keywords | Struttura |
|---|---|---|---|---|---|---|
| Metabolism and mechanism of the new agent CPX-351 for the treatment of acute myeloid leukemia: a novel approach to overcome leukemia resistance. | 2021 | Simone Mirabilii |
Acute Myeloid Leukemia (AML) is the most frequent malignant myeloid disease in the adult population. |
LS4_6, LS7_4 | METABOLISMO, EMATOLOGIA, CANCRO | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| Nutrient-induced carbonyl stress as mediator of the cardiometabolic risk linked to unhealthy modern diet | 2021 | Stefano Menini |
Increased consumption of calorie-dense foods is leading to an epidemic of cardiometabolic conditions including diabetes and cardiovascular disease. |
LS4_5, LS4_7, LS4_3 | ALIMENTAZIONE, MALATTIE METABOLICHE, BASI MOLECOLARI E CELLULARI DEI DIFETTI DEL METABOLISMO | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| Prognostic Value of Regional Layer-specific Myocardial 2D Strain Echocardiography and Cardiac Biomarkers for Early Detection of Epirubicin-Related Cardiac Toxicity in Patients Affected by Breast Cancer. | 2021 | Allegra Battistoni |
The development of tools for the early identification of patients at greater risk of cancer therapy-related cardiac dysfunction and heart failure is an area of active research in cardio-oncology. |
LS4_7, LS4_8, LS7_1 | CARDIOLOGIA, CHEMIOTERAPIA, FISIOLOGIA CARDIOCIRCOLATORIA | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| MicroRNAs as biomarkers of bone quality and response to exercise in patients with type 2 diabetes | 2021 | Jonida Haxhi |
Type 2 diabetes (T2D) mellitus is associated with an increased fracture risk, independently of bone mineral density (BMD). A reduction in bone quality might explain this discrepancy in T2D. |
LS4_5, LS2_2 | DIABETE, OSTEOPOROSI, BIOCHIMICA E BIOLOGIA MOLECOLARE CLINICA, BIOCHIMICA GENERALE E METABOLISMO | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| FGFR isoform switch in pancreatic ductal adenocarcinoma: role of FGFR2c aberrant expression and signaling in the establishment of EMT and dysregulated autophagy. | 2021 | Francesca Belleudi |
Pancreatic ductal adenocarcinoma (PDAC) is a treatment-resistant malignancy driven by the "undruggable", constitutively active KRAS, which made the search for new therapeutic strategies bypassing t |
LS4_6, LS3_5, LS1_10 | RECETTORI DI MEMBRANA, BASI BIOLOGICHE DEL CANCRO, TRASDUZIONE DEI SEGNALI | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| Prediction of life-threatening ventricular arrhythmia in patients with hypertrophic cardiomyopathy: role of three-dimensional architecture of scar conducting channels assessed with high resolution cardiac magnetic resonance | 2021 | Pietro Francia |
Myocardial scar is a common finding in patients with hypertrophic cardiomyopathy (HCM) and provides the substrate for ventricular arrhythmia (VA). |
LS4_7, LS7_1 | CARDIOLOGIA, FISIOLOGIA CARDIOCIRCOLATORIA, MALATTIE RARE | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| Ferroptosis: correlation between STK11-KEAP1 mutations and lipid metabolism in Lung Cancer Stem Cells (LCSCs). | 2021 | Rita Mancini |
Lung cancer is the leading cause of cancer mortality. |
LS4_6, LS2_15, LS1_10 | BASI BIOLOGICHE DEL CANCRO, BIOLOGIA DELLE CELLULE STAMINALI, METABOLISMO LIPIDICO, MEDICINA MOLECOLARE, GENOMICA | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| NOTCH3 pathogenic variants in multiple sclerosis patients: frequency, clinical features and disease-associated cellular phenotypes | 2021 | Simona Petrucci |
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) leading to inflammatory lesion in brain and spinal cord. |
LS2_1, LS5_7 | GENETICA MEDICA, NEUROLOGIA, GENETICA MOLECOLARE, NEURORADIOLOGIA, PATOLOGIA GENERALE | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| Pharmacological intervention to target the pro-calcific phenotypic drift of myeloid cells: a pilot study | 2021 | Carmen Mignogna |
Background: Cardiovascular disease (CVD) is the major cause of morbidity and mortality in subjects with type 2 diabetes (T2D). |
LS4_3 | DIABETE, ATEROSCLEROSI, MEDICINA MOLECOLARE | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |
| Sintesi e caratterizzazione di nanomateriali per applicazioni in biotecnologia e sensoristica. | 2021 | Tommaso Alberto Salamone |
I materiali nanostrutturati trovano impiego in diversi ambiti, quali l'optoelettronica, la sensoristica, la catalisi, la nanomedicina. |
PE5_6, PE5_10, PE5_8 | NANOPARTICELLE, NANOMATERIALI, CHIMICA DELLE SUPERFICI, BIOMATERIALI, NANOTECNOLOGIE | DIPARTIMENTO DI MEDICINA CLINICA E MOLECOLARE |