Alessandro Paiardini

Pubblicazioni

Titolo Pubblicato in Anno
Insights into pparγphosphorylation and its inhibition mechanism JOURNAL OF MEDICINAL CHEMISTRY 2020
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity CELL DEATH & DISEASE 2020
Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1 CELL REPORTS 2020
A single center retrospective review of patients from central italy tested for melanoma predisposition genes INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
PyMod 3: a complete suite for structural bioinformatics in PyMOL BIOINFORMATICS 2020
Structure and function of HD-GYP phosphodiesterases Microbial Cyclic Di-Nucleotide Signaling 2020
A novel CDKN2A in-frame deletion associated with pancreatic cancer-melanoma syndrome DERMATOLOGY ONLINE JOURNAL 2020
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism NUCLEIC ACIDS RESEARCH 2019
N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia FRONTIERS IN ONCOLOGY 2019
A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies MOLECULAR GENETICS AND METABOLISM 2019
R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features THE FEBS JOURNAL 2019
Prenatal whole exome sequencing detects a new homozygous fukutin (FKTN) mutation in a fetus with an ultrasound suspicion of familial Dandy-Walker malformation. MOLECULAR GENETICS & GENOMIC MEDICINE 2019
Revisiting the “satisfaction of spatial restraints” approach of MODELLER for protein homology modeling PLOS COMPUTATIONAL BIOLOGY 2019
Corrigendum to “Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation” [Mol. Genet. Metab. 122/1–2 (2017) 135–142] MOLECULAR GENETICS AND METABOLISM 2018
Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations IUBMB LIFE 2018
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2018
Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa THE FEBS JOURNAL 2018
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells THE FEBS JOURNAL 2018
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa PROTEINS 2018
Cysteine 180 is a redox sensor modulating activity of human pyridoxal 5'-phosphate histidine decarboxylase BIOCHEMISTRY 2018

ERC

  • LS1
  • LS1_8
  • LS1_12
  • LS1_14
  • LS2_11

KET

  • Big data & computing
  • Life-science technologies & biotechnologies

Interessi di ricerca

Bioinformatics, Computational Biology, Medicinal Chemistry, Drug Design, Protein Structure Prediction, Deep Learning, GUI programming, Python, Cancer, Kinases

Progetti di Ricerca

Gruppi di ricerca

Nutrient sensing and redox transducers in bacterial biofilm.

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