Alessandro Paiardini

Pubblicazioni

Titolo Pubblicato in Anno
The novel R347G pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 2016
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state THE FEBS JOURNAL 2015
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase CHEMMEDCHEM 2015
Structural basis of functional diversification of the HD-GYP domain revealed by the pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site JOURNAL OF BACTERIOLOGY 2015
Screening the medicines for malaria venture "malaria box" against the Pasmodium falciparum aminopeptidases, m1, m17 and m18 PLOS ONE 2015
Identification and validation of a potent dual Inhibitor of the P. falciparum M1 and M17 aminopeptidases using virtual screening PLOS ONE 2015
Synthesis of triazole-linked analogues of c-di-gmp and their interactions with diguanylate cyclase JOURNAL OF MEDICINAL CHEMISTRY 2015
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy. GENE 2015
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17 PROTEINS 2015

ERC

  • LS1
  • LS1_8
  • LS1_12
  • LS1_14
  • LS2_11

KET

  • Big data & computing
  • Life-science technologies & biotechnologies

Interessi di ricerca

Bioinformatics, Computational Biology, Medicinal Chemistry, Drug Design, Protein Structure Prediction, Deep Learning, GUI programming, Python, Cancer, Kinases

Progetti di Ricerca

Gruppi di ricerca

Nutrient sensing and redox transducers in bacterial biofilm.

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