Alessandro Paiardini

Pubblicazioni

Titolo Pubblicato in Anno
Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report BMC NEPHROLOGY 2018
Identification of small molecule inhibitors of the aurora-A/TPX2 complex ONCOTARGET 2017
Glucose metabolism in the progression of prostate cancer FRONTIERS IN PHYSIOLOGY 2017
Pyridoxine-5'-phosphate oxidase (pnpo) deficiency. clinical and biochemical alterations associated with the c.347g>a (pp. arg116gln) mutation MOLECULAR GENETICS AND METABOLISM 2017
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis SCIENTIFIC REPORTS 2017
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) DATA IN BRIEF 2017
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis SCIENTIFIC REPORTS 2017
Discovering selective diguanylate cyclase inhibitors: From PleD to discrimination of the active site of cyclic-di-GMP phosphodiesterases c-di-GMP signaling 2017
Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ ONCOGENESIS 2017
A novel germline mutation in CDK4 codon 24 associated to familial melanoma CLINICAL GENETICS 2017
PyMod 2.0: improvements in protein sequence-structure analysis and homology modeling within PyMOL BIOINFORMATICS 2017
New insights emerging from recent investigations on Human Group II pyridoxal 5'-phosphate decarboxylases CURRENT MEDICINAL CHEMISTRY 2017
Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii BIOCHEMICAL JOURNAL 2017
In silico discovery and in vitro validation of catechol-containing sulfonohydrazide compounds as potent inhibitors of the diguanylate cyclase PleD JOURNAL OF BACTERIOLOGY 2016
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells ONCOTARGET 2016
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 2016
Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy DATA IN BRIEF 2016
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2016
Genotype-phenotype correlation study through protein model of 3- methylcrotonyl-CoA carboxylase JOURNAL OF INHERITED METABOLIC DISEASE 2016

ERC

  • LS1
  • LS1_8
  • LS1_12
  • LS1_14
  • LS2_11

KET

  • Big data & computing
  • Life-science technologies & biotechnologies

Interessi di ricerca

Bioinformatics, Computational Biology, Medicinal Chemistry, Drug Design, Protein Structure Prediction, Deep Learning, GUI programming, Python, Cancer, Kinases

Progetti di Ricerca

Gruppi di ricerca

Nutrient sensing and redox transducers in bacterial biofilm.

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma