Gian Gaetano Tartaglia

Pubblicazioni

Titolo Pubblicato in Anno
Mid-infrared nanospectroscopy of individual DNA-binding protein oligomers 2022 47th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz) 2022
Probing TDP-43 condensation using an in silico designed aptamer NATURE COMMUNICATIONS 2022
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021
A computational approach to investigate tdp-43 rna-recognition motif 2 c-terminal fragments aggregation in amyotrophic lateral sclerosis BIOMOLECULES 2021
catRAPID omics v2.0: going deeper and wider in the prediction of protein–RNA interactions NUCLEIC ACIDS RESEARCH 2021
DualSeqDB: the host-pathogen dual RNA sequencing database for infection processes NUCLEIC ACIDS RESEARCH 2021
RNA-protein interactions: Central players in coordination of regulatory networks BIOESSAYS 2021
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins NUCLEIC ACIDS RESEARCH 2021
The Interplay Between Disordered Regions in RNAs and Proteins Modulates Interactions Within Stress Granules and Processing Bodies JOURNAL OF MOLECULAR BIOLOGY 2021
Aggregation is a context-dependent constraint on protein evolution FRONTIERS IN MOLECULAR BIOSCIENCES 2021
Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021
HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade CELL DEATH & DISEASE 2020
Structural analysis of SARS-CoV-2 genome and predictions of the human interactome NUCLEIC ACIDS RESEARCH 2020
RNA as the stone guest of protein aggregation NUCLEIC ACIDS RESEARCH 2020
Long non-coding RNA-polycomb intimate rendezvous OPEN BIOLOGY 2020
RNA-binding and prion domains: the Yin and Yang of phase separation NUCLEIC ACIDS RESEARCH 2020
Zooming in on protein–RNA interactions: a multilevel workflow to identify interaction partners BIOCHEMICAL SOCIETY TRANSACTIONS 2020
Transcriptomic differences in MSA clinical variants SCIENTIFIC REPORTS 2020
The protective role of m1A during stress-induced granulation JOURNAL OF MOLECULAR CELL BIOLOGY 2020
In silico, in vitro, and in vivo approaches to identify molecular players in fragile X tremor and Ataxia syndrome FRONTIERS IN MOLECULAR BIOSCIENCES 2020

ERC

  • LS1
  • LS2_1

Interessi di ricerca

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders.  My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS).  We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins.   One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

Progetti di Ricerca

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