Gian Gaetano Tartaglia
Professore Ordinario
| Titolo | Pubblicato in | Anno |
|---|---|---|
| By the company they keep: Interaction networks define the binding ability of transcription factors | NUCLEIC ACIDS RESEARCH | 2015 |
| Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets | BMC GENOMICS | 2015 |
| The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein | JOURNAL OF BIOLOGICAL CHEMISTRY | 2015 |
| Neurodegeneration and cancer: where the disorder prevails | SCIENTIFIC REPORTS | 2015 |
| ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function | NEURON | 2015 |
Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders. My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS). We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins. One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.
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