Gian Gaetano Tartaglia

Pubblicazioni

Titolo Pubblicato in Anno
Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs NUCLEIC ACIDS RESEARCH 2018
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions CELL 2018
An Integrative Study of Protein-RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome CELL REPORTS 2018
A method for RNA structure prediction shows evidence for structure in lncRNAs FRONTIERS IN MOLECULAR BIOSCIENCES 2018
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation NATURE STRUCTURAL & MOLECULAR BIOLOGY 2018
Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation NUCLEIC ACIDS RESEARCH 2018
Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy PARKINSONISM & RELATED DISORDERS 2018
Quantitative predictions of protein interactions with long noncoding RNAs NATURE METHODS 2017
Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma BRAIN 2017
Discovering the 3' UTR-mediated regulation of alpha-synuclein NUCLEIC ACIDS RESEARCH 2017
A high-throughput approach to profile RNA structure NUCLEIC ACIDS RESEARCH 2017
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2017
OmiXcore: A web server for prediction of protein interactions with large RNA BIOINFORMATICS 2017
Advances in the characterization of RNA-binding proteins WILEY INTERDISCIPLINARY REVIEWS. RNA 2016
Non-random distribution of homo-repeats: links with biological functions and human diseases SCIENTIFIC REPORTS 2016
CatRAPID signature: identification of ribonucleoproteins and RNA-binding regions BIOINFORMATICS 2016
The grand challenge of characterizing ribonucleoprotein networks FRONTIERS IN MOLECULAR BIOSCIENCES 2016
A concentration-dependent liquid phase separation can cause toxicity upon increased protein expression CELL REPORTS 2016
Molecular pathophysiology of fragile X-associated tremor/Ataxia syndrome and perspectives for drug development CEREBELLUM 2016
A computational approach for the discovery of protein–RNA networks Methods in Molecular Biology 2016

ERC

  • LS1
  • LS2_1

Interessi di ricerca

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders.  My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS).  We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins.   One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

Progetti di Ricerca

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