Susanna Scarpa | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Pyrrolyl and indolyl α-γ-diketo acid derivatives acting as selective inhibitors of human carbonic anhydrases IX and XII	PHARMACEUTICALS	2023
Belimumab decreases autophagy and citrullination in peripheral blood mononuclear cells from patients with systemic lupus erythematosus	CELLS	2022
Oxidative stress and visual system a review	EXCLI JOURNAL	2022
The kinesin Eg5 inhibitor K858 exerts antiproliferative and proapoptotic effects and attenuates the invasive potential of head and neck squamous carcinoma cells	INVESTIGATIONAL NEW DRUGS	2022
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Autophagy Hijacking in PBMC From COVID-19 Patients Results in Lymphopenia	FRONTIERS IN IMMUNOLOGY	2022
Tissue Expression of Androgen Receptor Splice Variant 7 at Radical Prostatectomy Predicts Risk of Progression in Untreated Nonmetastatic Prostate Cancer	ONCOLOGY	2021
Design, synthesis and biological evaluation of new pyrimidine derivatives as anticancer agents	MOLECULES	2021
Anti-tumoral effects of a (1H-pyrrol-1-yl)methyl-1H-benzoimidazole carbamate ester derivative on head and neck squamous carcinoma cell lines	PHARMACEUTICALS	2021
Pro-Inflammatory effects of 1-MHz Pulsed Ultrasound in Human Keratinocytes	5th International Caparica Conference on Ultrasonic-based Applications: from analysis to synthesis 2021	2021
Effect of 1‑MHz ultrasound on the proinflammatory interleukin‑6 secretion in human keratinocytes	SCIENTIFIC REPORTS	2021
Maladaptive autophagy in the pathogenesis of autoimmune epithelitis in Sjögren's syndrome	ARTHRITIS & RHEUMATOLOGY	2021
Discovery of a pyrimidine compound endowed with antitumor activity	INVESTIGATIONAL NEW DRUGS	2020
Androgen receptor variant 7 (AR-V7) in sequencing therapeutic agents for castratrion resistant prostate cancer: A critical review	MEDICINE	2019
Ultrasound delivery of Surface Enhanced InfraRed Absorption active gold-nanoprobes into fibroblast cells: a biological study via Synchrotron-based InfraRed microanalysis at single cell level	SCIENTIFIC REPORTS	2019
Immunotherapy in prostate cancer. Recent advances and future directions	EUROPEAN MEDICAL JOURNAL. UROLOGY	2019
Brain gliomas and growth factors: immunohistochemical, immunofluorescence, flow cytometry and RT-PCR profile in pediatric age	JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS	2019
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype	CLINICAL EPIGENETICS	2019
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells	INVESTIGATIONAL NEW DRUGS	2018
Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells	ANTI-CANCER DRUGS	2018

ERC

LS4_12

Interessi di ricerca

Attualmente testiamo l'attività anti-tumorale di composti di nuova sintesi su vari tipi di tumori umani in vitro. Ne valutiamo gli effetti su molte proprietà del fenotipo maligno, quali il controllo dei checkpoints del ciclo cellulare, l'induzione di apoptosi, il controllo sulle capacità di invasione locale, quali la transizione epitelio mesenchimale, la produzione di enzimi proteolitici e la invasione della matrice extracellulare.

Keywords

antitumor agents

apoptosis

extracellular matrix remodeling

tubulin inhibitors

Progetti di Ricerca

Laboratori di ricerca

Patologia Cellulare e Ultrastrutturale