Dante Rotili | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection	CELLS	2023
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation	DRUG DISCOVERY TODAY	2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8	JOURNAL OF MEDICINAL CHEMISTRY	2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells	JOURNAL OF MEDICINAL CHEMISTRY	2023
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.	MICROBIOLOGICAL RESEARCH	2023
The role of structural biology in the design of sirtuin activators	CURRENT OPINION IN STRUCTURAL BIOLOGY	2023
State of the art of carbonic anhydrase activators	FUTURE MEDICINAL CHEMISTRY	2023
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY	2023
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells	INFLAMMATION	2023
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase	ACS CHEMICAL BIOLOGY	2023
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress	ANTIOXIDANTS	2023
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY	2023
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3	CANCER COMMUNICATIONS	2023
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress	ANTIOXIDANTS	2023
Hydrophilic gold nanoparticles as Anti-PD-L1 antibody carriers. Synthesis and interface properties	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION	2022
Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications	PHYSICA MEDICA	2022
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription	NUCLEIC ACIDS RESEARCH	2022
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity	PHARMACEUTICALS	2022
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression	INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS	2022

Progetti di Ricerca

Modulators of epigenetic targets for the treatment of parasitic diseases.
Development of novel LSD1 inhibitors as potential new generation anticancer agents.
Development of glucose-based pure beta minus radiotracers potentially suitable for tumor radioguided surgery.