Dante Rotili | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity	JOURNAL OF MEDICINAL CHEMISTRY	2024
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer	CANCER CELL INTERNATIONAL	2024
Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2023
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence	JOURNAL OF MEDICINAL CHEMISTRY	2023
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey	JOURNAL OF MEDICINAL CHEMISTRY	2023
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2023
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design	GREEN CHEMISTRY	2023
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery	CELLS	2023
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2023
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection	CELLS	2023
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation	DRUG DISCOVERY TODAY	2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8	JOURNAL OF MEDICINAL CHEMISTRY	2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells	JOURNAL OF MEDICINAL CHEMISTRY	2023
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.	MICROBIOLOGICAL RESEARCH	2023
The role of structural biology in the design of sirtuin activators	CURRENT OPINION IN STRUCTURAL BIOLOGY	2023
State of the art of carbonic anhydrase activators	FUTURE MEDICINAL CHEMISTRY	2023
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY	2023
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells	INFLAMMATION	2023
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase	ACS CHEMICAL BIOLOGY	2023
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress	ANTIOXIDANTS	2023

Progetti di Ricerca

Modulators of epigenetic targets for the treatment of parasitic diseases.
Development of novel LSD1 inhibitors as potential new generation anticancer agents.
Development of glucose-based pure beta minus radiotracers potentially suitable for tumor radioguided surgery.