Dante Rotili | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Epigenetic polypharmacology: a new frontier for epi-drug discovery	MEDICINAL RESEARCH REVIEWS	2019
α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors	ACS MEDICINAL CHEMISTRY LETTERS	2019
DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation	The DNA, RNA, and Histone Methylomes	2019
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer	CANCERS	2019
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis	CLINICAL EPIGENETICS	2019
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells	EUROPEAN JOURNAL OF PHARMACOLOGY	2019
Effects of glutathione transferase-targeting nitrobenzoxadiazole compounds in relation to PD-L1 status in human melanoma cells	CHEMOTHERAPY	2019
H19-dependent transcriptional regulation of β3 and β4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2019
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2019
Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors	Topics in Medicinal Chemistry	2019
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches	JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN	2018
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer	CLINICAL CANCER RESEARCH	2018
Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β − tracer suitable in radio-guided surgery	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS	2018
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2	CLINICAL EPIGENETICS	2018
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications	FUTURE MEDICINAL CHEMISTRY	2018
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells	CELL DEATH & DISEASE	2018
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.	BIOORGANIC & MEDICINAL CHEMISTRY	2017
Structural basis of sirtuin 6 activation by synthetic small molecules.	ANGEWANDTE CHEMIE. INTERNATIONAL EDITION	2017
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.	ONCOTARGET	2017

Progetti di Ricerca

Modulators of epigenetic targets for the treatment of parasitic diseases.
Development of novel LSD1 inhibitors as potential new generation anticancer agents.
Development of glucose-based pure beta minus radiotracers potentially suitable for tumor radioguided surgery.