Dante Rotili


Titolo Pubblicato in Anno
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 CLINICAL EPIGENETICS 2018
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications FUTURE MEDICINAL CHEMISTRY 2018
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells CELL DEATH & DISEASE 2018
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. BIOORGANIC & MEDICINAL CHEMISTRY 2017
Structural basis of sirtuin 6 activation by synthetic small molecules. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION 2017
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis. ONCOTARGET 2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity JOURNAL OF MEDICINAL CHEMISTRY 2017
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2017
Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides PHYSICA MEDICA 2017
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. JOURNAL OF MEDICINAL CHEMISTRY 2017
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. NATURE COMMUNICATIONS 2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma SCIENTIFIC REPORTS 2017
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition JOURNAL OF TRANSLATIONAL MEDICINE 2016
Sirtuin functions and modulation: from chemistry to the clinic CLINICAL EPIGENETICS 2016
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells AMERICAN JOURNAL OF CANCER RESEARCH 2016
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells ONCOTARGET 2016
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases BIOCHEMICAL PHARMACOLOGY 2016

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