Dante Rotili | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells	CELL DEATH & DISEASE	2018
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.	BIOORGANIC & MEDICINAL CHEMISTRY	2017
Structural basis of sirtuin 6 activation by synthetic small molecules.	ANGEWANDTE CHEMIE. INTERNATIONAL EDITION	2017
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.	ONCOTARGET	2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.	SCIENTIFIC REPORTS	2017
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity	JOURNAL OF MEDICINAL CHEMISTRY	2017
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system	COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS	2017
Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides	PHYSICA MEDICA	2017
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2017
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives.	JOURNAL OF MEDICINAL CHEMISTRY	2017
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.	NATURE COMMUNICATIONS	2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma	SCIENTIFIC REPORTS	2017
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition	JOURNAL OF TRANSLATIONAL MEDICINE	2016
Sirtuin functions and modulation: from chemistry to the clinic	CLINICAL EPIGENETICS	2016
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells	AMERICAN JOURNAL OF CANCER RESEARCH	2016
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells	ONCOTARGET	2016
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases	BIOCHEMICAL PHARMACOLOGY	2016
At long last potent and selective KDM5 inhibitors	CELL CHEMICAL BIOLOGY	2016
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features	SCIENCE ADVANCES	2016

Progetti di Ricerca

Modulators of epigenetic targets for the treatment of parasitic diseases.
Development of novel LSD1 inhibitors as potential new generation anticancer agents.
Development of glucose-based pure beta minus radiotracers potentially suitable for tumor radioguided surgery.