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Dante.Rotili@uniroma1.it
Dante Rotili
Professore Associato
Struttura:
DIPARTIMENTO DI CHIMICA E TECNOLOGIE DEL FARMACO
E-mail:
Dante.Rotili@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
CELL DEATH & DISEASE
2018
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.
BIOORGANIC & MEDICINAL CHEMISTRY
2017
Structural basis of sirtuin 6 activation by synthetic small molecules.
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION
2017
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
2017
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.
ONCOTARGET
2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.
SCIENTIFIC REPORTS
2017
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity
JOURNAL OF MEDICINAL CHEMISTRY
2017
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system
COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS
2017
Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides
PHYSICA MEDICA
2017
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2017
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives.
JOURNAL OF MEDICINAL CHEMISTRY
2017
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
NATURE COMMUNICATIONS
2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma
SCIENTIFIC REPORTS
2017
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
JOURNAL OF TRANSLATIONAL MEDICINE
2016
Sirtuin functions and modulation: from chemistry to the clinic
CLINICAL EPIGENETICS
2016
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells
AMERICAN JOURNAL OF CANCER RESEARCH
2016
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells
ONCOTARGET
2016
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases
BIOCHEMICAL PHARMACOLOGY
2016
At long last potent and selective KDM5 inhibitors
CELL CHEMICAL BIOLOGY
2016
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
SCIENCE ADVANCES
2016
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Progetti di Ricerca
Modulators of epigenetic targets for the treatment of parasitic diseases.
Development of novel LSD1 inhibitors as potential new generation anticancer agents.
Development of glucose-based pure beta minus radiotracers potentially suitable for tumor radioguided surgery.
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