Sergio Valente

Pubblicazioni

Titolo Pubblicato in Anno
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2024
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process JOURNAL OF MEDICINAL CHEMISTRY 2024
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2024
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy NATURE COMMUNICATIONS 2024
Uracil- and Pyridine-Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells CHEMMEDCHEM 2024
Heterocycles-Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years CHEMMEDCHEM 2024
Pharmacological Activation of SIRT3 Modulates the Response of Cancer Cells to Acidic pH PHARMACEUTICALS 2024
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey JOURNAL OF MEDICINAL CHEMISTRY 2023
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design GREEN CHEMISTRY 2023
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery CELLS 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors CURRENT OPINION IN STRUCTURAL BIOLOGY 2023
SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS ANTIOXIDANTS 2023
Targeting ROS production through inhibition of NADPH oxidases NATURE CHEMICAL BIOLOGY 2023
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2023
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2023
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE 2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules THERANOSTICS 2022

Progetti di Ricerca

Laboratori di ricerca

LABORATORIO 256

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