Pubblicazioni

Redox imbalance and metabolic defects in the context of Alzheimer disease

2024 - FEBS LETTERS

Di Domenico, F.; Lanzillotta, C.; Perluigi, M.

Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimerâs Disease

2024 - ANTIOXIDANTS

Staurenghi, E.; Testa, G.; Leoni, V.; Cecci, R.; Floro, L.; Giannelli, S.; Barone, E.; Perluigi, M.; Leonarduzzi, G.; Sottero, B.; Gamba, P.

Altered mitochondrial unfolded protein response and protein quality control promote oxidative distress in down syndrome brain

2024 - FREE RADICAL BIOLOGY & MEDICINE

Lanzillotta, Simona; Esteve, Daniel; Lanzillotta, Chiara; Tramutola, Antonella; Lloret, Ana; Forte, Elena; Pesce, Vito; Picca, Anna; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio

Intranasal administration of KYCCSRK peptide rescues brain insulin signaling activation and reduces Alzheimerâs disease-like neuropathology in a mouse model for Down syndrome

2023 - ANTIOXIDANTS

Tramutola, Antonella; Lanzillotta, Simona; Aceto, Giuseppe; Pagnotta, Sara; Ruffolo, Gabriele; Cifelli, Pierangelo; Marini, Federico; Ripoli, Cristian; Palma, Eleonora; Grassi, Claudio; DI DOMENICO, Fabio; Perluigi, Marzia; Barone, Eugenio

Brain insulin resistance: An early risk factor for Alzheimer's disease development in down syndrome

2022 - NEURAL REGENERATION RESEARCH

Barone, E.

CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down syndrome

2022 - FREE RADICAL BIOLOGY & MEDICINE

Pagnotta, S.; Tramutola, A.; Barone, E.; Di Domenico, F.; Pittala, V.; Salerno, L.; Folgiero, V.; Caforio, M.; Locatelli, F.; Petrini, S.; Butterfield, D. A.; Perluigi, M.

DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome

2022 - FRONTIERS IN GENETICS

Ravaioli, F.; Zampieri, M.; Morandi, L.; Pirazzini, C.; Pellegrini, C.; De Fanti, S.; Gensous, N.; Pirazzoli, G. L.; Sambati, L.; Ghezzo, A.; Ciccarone, F.; Reale, A.; Monti, D.; Salvioli, S.; Caiafa, P.; Capri, M.; Burkle, A.; Moreno-Villanueva, M.; Garagnani, P.; Franceschi, C.; Bacalini, M. G.

Evaluation of test-retest reliability and concurrent validity of the Italian version of the pediatric evaluation of disability inventory in children with down syndrome: a cross-sectional study

2022 - JOURNAL OF PEDIATRIC REHABILITATION MEDICINE

Galeoto, Giovanni; Mignolli, Ester; Tofani, Marco; Sogos, Carla; Servadio, Annamaria; Valente, Donatella; Berardi, Anna

Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome

2021 - FREE RADICAL BIOLOGY & MEDICINE

Lanzillotta, Chiara; Tramutola, Antonella; Di Giacomo, Graziella; Marini, Federico; Butterfield, D Allan; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio

Stress responses in down syndrome neurodegeneration: State of the art and therapeutic molecules

2021 - BIOMOLECULES

Lanzillotta, C.; Di Domenico, F.

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

2021 - GEROSCIENCE

Giulia Bacalini, Maria; Reale, Anna; Malavolta, Marco; Ciccarone, Fabio; Moreno-Villanueva, MarÃa; DollÃ©, Martijn E. T.; Jansen, EugÃ¨ne; Grune, Tilman; Gonos, Efstathios S.; SchÃ¶n, Christiane; Bernhardt, JÃ¼rgen; Grubeck-Loebenstein, Beatrix; Sikora, Ewa; Toussaint, Olivier; Debacq-Chainiaux, Florence; Capri, Miriam; Hervonen, Antti; Hurme, Mikko; Eline Slagboom, P.; Breusing, Nicolle; Aversano, Valentina; Tagliatesta, Stefano; Franceschi, Claudio; Blasco, Maria A.; BÃ¼rkle, Alexander; Caiafa, Paola; Zampieri, Michele

Cardiac defects and genetic syndromes: old uncertainties and new insights

2021 - GENES

Calcagni, G.; Pugnaloni, F.; Digilio, M. C.; Unolt, M.; Putotto, C.; Niceta, M.; Baban, A.; Sparascio, F. P.; Drago, F.; De Luca, A.; Tartaglia, M.; Marino, B.; Versacci, P.

Editorial: Brain insulin resistance in neurodevelopmental and neurodegenerative disorders: mind the gap!

2021 - FRONTIERS IN NEUROSCIENCE

Dierssen, M.; Barone, E.

Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimerâs dysmetabolism, neuropathology, and possible therapies

2021 - FREE RADICAL BIOLOGY & MEDICINE

Perluigi, M.; Di Domenico, F.; Butterfield, D. A.

Effects of resistance training in muscle mass and markers of muscle damage in adults with down syndrome

2021 - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH

Diaz, A. J.; Rosety, I.; Ordonez, F. J.; Brenes, F.; Garcia-Gomez, N.; Castejon-Riber, C.; Rosety-Rodriguez, M.; Bernardi, M.; Alvero-Cruz, J. R.; Rosety, M. A.

Neuroinflammatory markers in the serum of prepubertal children with down syndrome

2020 - JOURNAL OF IMMUNOLOGY RESEARCH

Tarani, L.; Carito, V.; Ferraguti, G.; Petrella, C.; Greco, A.; Ralli, M.; Messina, M. P.; Rasio, D.; De Luca, E.; Putotto, C.; Versacci, P.; Ceccanti, M.; Fiore, M.

The dysregulation of OGT/OGA cycle mediates Tau and APP neuropathology in down syndrome

2020 - NEUROTHERAPEUTICS

Zuliani, I.; Lanzillotta, C.; Tramutola, A.; Francioso, A.; Pagnotta, S.; Barone, E.; Perluigi, M.; Di Domenico, F.

Proteomics study of peripheral blood mononuclear cells in down syndrome children

2020 - ANTIOXIDANTS

Lanzillotta, C.; Greco, V.; Valentini, D.; Villani, A.; Folgiero, V.; Caforio, M.; Locatelli, F.; Pagnotta, S.; Barone, E.; Urbani, A.; Domenico, F. D.; Perluigi, M.

Differences in morbidity and mortality in Down syndrome are related to the type of congenital heart defect

2020 - AMERICAN JOURNAL OF MEDICAL GENETICS. PART A

Baban, A.; Olivini, N.; Cantarutti, N.; Cali, F.; Vitello, C.; Valentini, D.; Adorisio, R.; Calcagni, G.; Alesi, V.; Di Mambro, C.; Villani, A.; Dallapiccola, B.; Digilio, M. C.; Marino, B.; Carotti, A.; Drago, F.

PNPLA3 gene polymorphism is associated with liver steatosis in children with Down syndrome

2020 - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Valentini, Diletta; Mosca, Antonella; Di Camillo, Chiara; Crudele, Annalisa; Sartorelli, Maria Rita; Scoppola, Vittorio; Tarani, Luigi; Villani, Alberto; Raponi, Massimiliano; Novelli, Antonio; Alisi, Anna

Clinical characteristics of individuals with Down syndrome deceased with CoVIDâ19 in ItalyâA case series