Rino Ragno | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Foeniculum vulgare miller, a new chemotype from Montenegro	PLANTS	2022
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription	NUCLEIC ACIDS RESEARCH	2022
Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules	THERANOSTICS	2022
Essential Oils Biofilm Modulation Activity and Machine Learning Analysis on Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients	MICROORGANISMS	2022
In vivo Antiphytoviral Activity of Essential Oils and Hydrosols From Origanum vulgare, Thymus vulgaris, and Rosmarinus officinalis to Control Zucchini Yellow Mosaic Virus and Tomato Leaf Curl New Delhi Virus in Cucurbita pepo L	FRONTIERS IN MICROBIOLOGY	2022
Chemical Composition of Various Nepeta cataria Plant Organs’ Methanol Extracts Associated with In Vivo Hepatoprotective and Antigenotoxic Features as well as Molecular Modeling Investigations	PLANTS	2022
Pinus mugo Essential Oil Impairs STAT3 Activation through Oxidative Stress and Induces Apoptosis in Prostate Cancer Cells	MOLECULES	2022
Bovine serum amine oxidase and polyamine analogues: chemical synthesis and biological evaluation integrated with molecular docking and 3-D QSAR studies	JOURNAL OF CHEMICAL INFORMATION AND MODELING	2022
Ligand-based and structure-based studies to develop predictive models for {SARS}-{CoV}-2 main protease inhibitors through the 3d-qsar.com portal	JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN	2022
Human Estrogen Receptor Alpha Antagonists, Part 3: 3-D Pharmacophore and 3-D QSAR Guided Brefeldin A Hit-to-Lead Optimization toward New Breast Cancer Suppressants	MOLECULES	2022
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53	JOURNAL OF MEDICINAL CHEMISTRY	2021
Anti-virulence properties of Coridothymus capitatus essential oil against Pseudomonas aeruginosa clinical isolates from cystic fibrosis patients	MICROORGANISMS	2021
A comparative analysis of punicalagin interaction with PDIA1 and PDIA3 by biochemical and computational approaches	BIOMEDICINES	2021
Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models	CELL DEATH DISCOVERY	2021
Human Estrogen Receptor α Antagonists. Part 1: 3-D QSAR-Driven Rational Design of Innovative Coumarin-Related Antiestrogens as Breast Cancer Suppressants through Structure-Based and Ligand-Based Studies	JOURNAL OF CHEMICAL INFORMATION AND MODELING	2021
Gas-phase structures and thermochemical properties of protonated 5-hmf isomers	INTERNATIONAL JOURNAL OF MASS SPECTROMETRY	2020
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene	HUMAN GENETICS	2020
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization	ACS CHEMICAL BIOLOGY	2020

ERC

LS1_13
LS2_11
PE4_13
PE5_18

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Design of small molecules as potential bioactive agents

Developing of methods to predict the activity of new molecules

Machine learning applications to develop model for complex mixtures

Keywords

drug design

drug design and discovery

computational chemistry

essential oil active components (EO-ACs)

essential oil

Molecular docking

drug repurposing

quantitative composition-activity relationships

Progetti di Ricerca

Laboratori di ricerca

3D-QSAR PORTAL