Speranza Donatella Rubattu | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
The ATP synthase glycine zipper of the c subunits: from the structural to the functional role in mitochondrial biology of cardiovascular diseases	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH	2021
A Contemporary View of Natriuretic Peptides in the SARS-CoV-2 Era	FRONTIERS IN PHYSIOLOGY	2021
Trehalose, a natural disaccharide, reduces stroke occurrence in the stroke-prone spontaneously hypertensive rat	PHARMACOLOGICAL RESEARCH	2021
Novel Imaging and Genetic Risk Markers in Takotsubo Syndrome	FRONTIERS IN CARDIOVASCULAR MEDICINE	2021
An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation	CELL DEATH & DISEASE	2021
Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke	PFLÜGERS ARCHIV	2021
Novel ANP (Atrial Natriuretic Peptide) based therapy for hypertension: the promising role of a disease mechanism targeted approach	HYPERTENSION	2021
Targeting cyclic guanylate monophosphate in resistant hypertension and heart failure. Are sacubitril/valsartan and vericiguat synergistic and effective in both conditions?	HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION	2021
[Prevention Italy 2021 - An update of the 2018 Consensus document and recommendations for the prevention of cardiovascular disease in Italy]	GIORNALE ITALIANO DI CARDIOLOGIA	2021
BNP level and post-transcatheter aortic valve replacement outcome: an intriguing J-shaped relationship	EUROPEAN HEART JOURNAL	2020
Pathogenesis of ischemic stroke: role of epigenetic mechanisms	GENES	2020
Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation	JOURNAL OF CLINICAL MEDICINE	2020
Risk stratification in hypertrophic cardiomyopathy. Insights from genetic analysis and cardiopulmonary exercise testing	JOURNAL OF CLINICAL MEDICINE	2020
Vascular ageing in hypertension. focus on mitochondria	MECHANISMS OF AGEING AND DEVELOPMENT	2020
The role of mitochondrial dynamics in cardiovascular diseases	BRITISH JOURNAL OF PHARMACOLOGY	2020
Epigenetic control of natriuretic peptides: implications for health and disease	CELLULAR AND MOLECULAR LIFE SCIENCES	2020
Brain overexpression of uncoupling protein-2 (UCP2) delays renal damage and stroke occurrence in stroke-prone spontaneously hypertensive rats	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2020
Blockade of the neurohormonal systems in heart failure with preserved ejection fraction. A contemporary meta-analysis	INTERNATIONAL JOURNAL OF CARDIOLOGY	2020
Natriuretic Peptides, Cognitive Impairment and Dementia. An Intriguing Pathogenic Link with Implications in Hypertension	JOURNAL OF CLINICAL MEDICINE	2020
Recommendations for Cardiovascular Prevention During the Sars-Cov-2 Pandemic. An Executive Document by the Board of the Italian Society of Cardiovascular Prevention	HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION	2020

ERC

LS4_10

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.

Keywords

cardiovascular diseases

molecular mechanisms

animal models

mitochondria

natriuretic peptides

oxidative stress

genetics

autophagy

mitophagy

Progetti di Ricerca

Gruppi di ricerca

Disregolazione neurormonale nelle malattie cardiovascolari

Disfunzione mitocondriale e stress ossidativo nelle malattie cardiovascolari