Speranza Donatella Rubattu

Pubblicazioni

Titolo Pubblicato in Anno
The ATP synthase glycine zipper of the c subunits: from the structural to the functional role in mitochondrial biology of cardiovascular diseases BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2021
A Contemporary View of Natriuretic Peptides in the SARS-CoV-2 Era FRONTIERS IN PHYSIOLOGY 2021
Trehalose, a natural disaccharide, reduces stroke occurrence in the stroke-prone spontaneously hypertensive rat PHARMACOLOGICAL RESEARCH 2021
Novel Imaging and Genetic Risk Markers in Takotsubo Syndrome FRONTIERS IN CARDIOVASCULAR MEDICINE 2021
An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation CELL DEATH & DISEASE 2021
Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke PFLÜGERS ARCHIV 2021
Novel ANP (Atrial Natriuretic Peptide) based therapy for hypertension: the promising role of a disease mechanism targeted approach HYPERTENSION 2021
Targeting cyclic guanylate monophosphate in resistant hypertension and heart failure. Are sacubitril/valsartan and vericiguat synergistic and effective in both conditions? HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2021
[Prevention Italy 2021 - An update of the 2018 Consensus document and recommendations for the prevention of cardiovascular disease in Italy] GIORNALE ITALIANO DI CARDIOLOGIA 2021
BNP level and post-transcatheter aortic valve replacement outcome: an intriguing J-shaped relationship EUROPEAN HEART JOURNAL 2020
Pathogenesis of ischemic stroke: role of epigenetic mechanisms GENES 2020
Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation JOURNAL OF CLINICAL MEDICINE 2020
Risk stratification in hypertrophic cardiomyopathy. Insights from genetic analysis and cardiopulmonary exercise testing JOURNAL OF CLINICAL MEDICINE 2020
Vascular ageing in hypertension. focus on mitochondria MECHANISMS OF AGEING AND DEVELOPMENT 2020
The role of mitochondrial dynamics in cardiovascular diseases BRITISH JOURNAL OF PHARMACOLOGY 2020
Epigenetic control of natriuretic peptides: implications for health and disease CELLULAR AND MOLECULAR LIFE SCIENCES 2020
Brain overexpression of uncoupling protein-2 (UCP2) delays renal damage and stroke occurrence in stroke-prone spontaneously hypertensive rats INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Blockade of the neurohormonal systems in heart failure with preserved ejection fraction. A contemporary meta-analysis INTERNATIONAL JOURNAL OF CARDIOLOGY 2020
Natriuretic Peptides, Cognitive Impairment and Dementia. An Intriguing Pathogenic Link with Implications in Hypertension JOURNAL OF CLINICAL MEDICINE 2020
Recommendations for Cardiovascular Prevention During the Sars-Cov-2 Pandemic. An Executive Document by the Board of the Italian Society of Cardiovascular Prevention HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2020

ERC

  • LS4_10

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.

 

Keywords

cardiovascular diseases
molecular mechanisms
animal models
mitochondria
natriuretic peptides
oxidative stress
genetics
autophagy
mitophagy

Gruppi di ricerca

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