Speranza Donatella Rubattu


Titolo Pubblicato in Anno
Novel ANP (Atrial Natriuretic Peptide) based therapy for hypertension: the promising role of a disease mechanism targeted approach HYPERTENSION 2021
Targeting cyclic guanylate monophosphate in resistant hypertension and heart failure. Are sacubitril/valsartan and vericiguat synergistic and effective in both conditions? HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2021
[Prevention Italy 2021 - An update of the 2018 Consensus document and recommendations for the prevention of cardiovascular disease in Italy] GIORNALE ITALIANO DI CARDIOLOGIA 2021
BNP level and post-transcatheter aortic valve replacement outcome: an intriguing J-shaped relationship EUROPEAN HEART JOURNAL 2020
Pathogenesis of ischemic stroke: role of epigenetic mechanisms GENES 2020
Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation JOURNAL OF CLINICAL MEDICINE 2020
Risk stratification in hypertrophic cardiomyopathy. Insights from genetic analysis and cardiopulmonary exercise testing JOURNAL OF CLINICAL MEDICINE 2020
Vascular ageing in hypertension. focus on mitochondria MECHANISMS OF AGEING AND DEVELOPMENT 2020
The role of mitochondrial dynamics in cardiovascular diseases BRITISH JOURNAL OF PHARMACOLOGY 2020
Epigenetic control of natriuretic peptides: implications for health and disease CELLULAR AND MOLECULAR LIFE SCIENCES 2020
Brain overexpression of uncoupling protein-2 (UCP2) delays renal damage and stroke occurrence in stroke-prone spontaneously hypertensive rats INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Blockade of the neurohormonal systems in heart failure with preserved ejection fraction. A contemporary meta-analysis INTERNATIONAL JOURNAL OF CARDIOLOGY 2020
Natriuretic Peptides, Cognitive Impairment and Dementia. An Intriguing Pathogenic Link with Implications in Hypertension JOURNAL OF CLINICAL MEDICINE 2020
Recommendations for Cardiovascular Prevention During the Sars-Cov-2 Pandemic. An Executive Document by the Board of the Italian Society of Cardiovascular Prevention HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2020
Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease CELLULAR AND MOLECULAR NEUROBIOLOGY 2020
Sacubitril/Valsartan: Potential Impact of ARNi "Beyond the Wall" of ACE2 on Treatment and Prognosis of Heart Failure Patients With Coronavirus Disease-19 FRONTIERS IN CARDIOVASCULAR MEDICINE 2020
T2238C atrial natriuretic peptide gene variant and cardiovascular events in patients with atrial fibrillation: A substudy from the ATHERO-AF cohort INTERNATIONAL JOURNAL OF CARDIOLOGY 2020
A novel promising frontier for human health: The beneficial effects of nutraceuticals in cardiovascular diseases INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Inhibition of miR-155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE 2020
Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019


  • LS4_10


  • Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.



cardiovascular diseases
molecular mechanisms
animal models
natriuretic peptides
oxidative stress

Gruppi di ricerca

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