Speranza Donatella Rubattu


Titolo Pubblicato in Anno
T2238C Atrial Natriuretic Peptide Gene Variant and the Response to Antiplatelet Therapy in Stable Ischemic Heart Disease Patients JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH 2018
Trehalose-induced activation of autophagy improves cardiac remodeling after myocardial infarction JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2018
Role of oxidative stress in the process of vascular remodeling following coronary revascularization. INTERNATIONAL JOURNAL OF CARDIOLOGY 2018
Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat JOURNAL OF HYPERTENSION 2018
Consensus document and recommendations for the prevention of cardiovascular disease in Italy - 2018 GIORNALE ITALIANO DI CARDIOLOGIA 2018
Cellular and subcellular localization of uncoupling protein 2 in the human kidney JOURNAL OF MOLECULAR HISTOLOGY 2018
Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor FRONTIERS IN CELLULAR NEUROSCIENCE 2018
Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes ONCOTARGET 2018
Natriuretic peptides in heart failure: Current achievements and future perspectives INTERNATIONAL JOURNAL OF CARDIOLOGY 2018
Executive Summary of the 2018 Joint Consensus Document on Cardiovascular Disease Prevention in Italy HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2018
Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like Kinase 1 (ALK1) Pathway FRONTIERS IN PHARMACOLOGY 2017
Resetting the neurohormonal balance in heart failure (HF). the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF HEART FAILURE REVIEWS 2017
Rac1 pharmacological inhibition rescues human endothelial dysfunction JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE 2017
A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines JOURNAL OF HYPERTENSION 2017
Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat CELL DEATH & DISEASE 2017
A decrease of brain MicroRNA-122 level is an early marker of cerebrovascular disease in the stroke-prone spontaneously hypertensive rat OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH:ubiquinone oxidoreductase Ndufc2 subunit HUMAN MOLECULAR GENETICS 2017
C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP SCIENTIFIC REPORTS 2017
Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients JOURNAL OF CARDIOVASCULAR MEDICINE 2016


  • LS4_10


  • Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.



cardiovascular diseases
molecular mechanisms
animal models
natriuretic peptides
oxidative stress

Gruppi di ricerca

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