Speranza Donatella Rubattu


Titolo Pubblicato in Anno
New therapies for arterial hypertension PANMINERVA MEDICA 2016
Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation. Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme CIRCULATION RESEARCH 2016
Ndufc2 Gene Inhibition Is associated with mitochondrial dysfunction and increased stroke susceptibility in an animal model of complex human disease JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE 2016
NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation CARDIOVASCULAR REVASCULARIZATION MEDICINE 2016
A next-generation sequencing approach to identify gene mutations in early-and late-onset hypertrophic cardiomyopathy patients of an Italian cohort INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2016
Mitochondrial dysfunction contributes to hypertensive target organ damage: lessons from an animal model of human disease OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2016
Natriuretic peptides and integrated risk assessment for cardiovascular disease. an individual-participant-data meta-analysis THE LANCET DIABETES & ENDOCRINOLOGY 2016
Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells MECHANISMS OF AGEING AND DEVELOPMENT 2016
An easy and reproducible parameter for the assessment of the pressure gradient in patients with aortic stenosis disease: a magnetic resonance study JOURNAL OF CARDIOLOGY 2015
RyR2 common gene variant G1886S and the risk of ventricular arrhythmias in ICD patients with heart failure. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 2015
Hypovitaminosis D and organ damage In patients with arterial hypertension: a multicenter double blind randomised controlled trial of cholecalciferol supplementation (HYPODD). Study design, clinical procedures and treatment protocol HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2015
Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis JOURNAL OF HYPERTENSION 2015
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains ONCOTARGET 2015
Angiotensin II receptor blocker neprilysin inhibitor (ARNI). new avenues in cardiovascular therapy HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2015
Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art BIOMED RESEARCH INTERNATIONAL 2015
C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro CELL DEATH & DISEASE 2015


  • LS4_10


  • Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.



cardiovascular diseases
molecular mechanisms
animal models
natriuretic peptides
oxidative stress

Gruppi di ricerca

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