Speranza Donatella Rubattu

Pubblicazioni

Titolo Pubblicato in Anno
Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor FRONTIERS IN CELLULAR NEUROSCIENCE 2018
Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like Kinase 1 (ALK1) Pathway FRONTIERS IN PHARMACOLOGY 2017
Resetting the neurohormonal balance in heart failure (HF). the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF HEART FAILURE REVIEWS 2017
Rac1 pharmacological inhibition rescues human endothelial dysfunction JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE 2017
A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines JOURNAL OF HYPERTENSION 2017
Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat CELL DEATH & DISEASE 2017
A decrease of brain MicroRNA-122 level is an early marker of cerebrovascular disease in the stroke-prone spontaneously hypertensive rat OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH:ubiquinone oxidoreductase Ndufc2 subunit HUMAN MOLECULAR GENETICS 2017
C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP SCIENTIFIC REPORTS 2017
Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients JOURNAL OF CARDIOVASCULAR MEDICINE 2016
New therapies for arterial hypertension PANMINERVA MEDICA 2016
Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation. Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme CIRCULATION RESEARCH 2016
Ndufc2 Gene Inhibition Is associated with mitochondrial dysfunction and increased stroke susceptibility in an animal model of complex human disease JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE 2016
NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation CARDIOVASCULAR REVASCULARIZATION MEDICINE 2016
A next-generation sequencing approach to identify gene mutations in early-and late-onset hypertrophic cardiomyopathy patients of an Italian cohort INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2016
Mitochondrial dysfunction contributes to hypertensive target organ damage: lessons from an animal model of human disease OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2016
Natriuretic peptides and integrated risk assessment for cardiovascular disease. an individual-participant-data meta-analysis THE LANCET DIABETES & ENDOCRINOLOGY 2016
Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells MECHANISMS OF AGEING AND DEVELOPMENT 2016
An easy and reproducible parameter for the assessment of the pressure gradient in patients with aortic stenosis disease: a magnetic resonance study JOURNAL OF CARDIOLOGY 2015

ERC

  • LS4_10

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.

 

Keywords

cardiovascular diseases
molecular mechanisms
animal models
mitochondria
natriuretic peptides
oxidative stress
genetics
autophagy
mitophagy

Gruppi di ricerca

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