Speranza Donatella Rubattu | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Consensus document and recommendations for the prevention of cardiovascular disease in Italy - 2018	GIORNALE ITALIANO DI CARDIOLOGIA	2018
Cellular and subcellular localization of uncoupling protein 2 in the human kidney	JOURNAL OF MOLECULAR HISTOLOGY	2018
Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor	FRONTIERS IN CELLULAR NEUROSCIENCE	2018
Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes	ONCOTARGET	2018
Natriuretic peptides in heart failure: Current achievements and future perspectives	INTERNATIONAL JOURNAL OF CARDIOLOGY	2018
Executive Summary of the 2018 Joint Consensus Document on Cardiovascular Disease Prevention in Italy	HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION	2018
Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor	FRONTIERS IN CELLULAR NEUROSCIENCE	2018
Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like Kinase 1 (ALK1) Pathway	FRONTIERS IN PHARMACOLOGY	2017
Resetting the neurohormonal balance in heart failure (HF). the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF	HEART FAILURE REVIEWS	2017
Rac1 pharmacological inhibition rescues human endothelial dysfunction	JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE	2017
A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines	JOURNAL OF HYPERTENSION	2017
Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat	CELL DEATH & DISEASE	2017
A decrease of brain MicroRNA-122 level is an early marker of cerebrovascular disease in the stroke-prone spontaneously hypertensive rat	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY	2017
In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH:ubiquinone oxidoreductase Ndufc2 subunit	HUMAN MOLECULAR GENETICS	2017
C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP	SCIENTIFIC REPORTS	2017
Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY	2017
T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients	JOURNAL OF CARDIOVASCULAR MEDICINE	2016
New therapies for arterial hypertension	PANMINERVA MEDICA	2016
Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation. Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme	CIRCULATION RESEARCH	2016
Ndufc2 Gene Inhibition Is associated with mitochondrial dysfunction and increased stroke susceptibility in an animal model of complex human disease	JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE	2016

ERC

LS4_10

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.

Keywords

cardiovascular diseases

molecular mechanisms

animal models

mitochondria

natriuretic peptides

oxidative stress

genetics

autophagy

mitophagy

Progetti di Ricerca

Gruppi di ricerca

Disregolazione neurormonale nelle malattie cardiovascolari

Disfunzione mitocondriale e stress ossidativo nelle malattie cardiovascolari