Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells CANCER GENE THERAPY 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Modulation of virulence-associated traits in Aspergillus fumigatus by BET Inhibitor JQ1 MICROORGANISMS 2022
Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response FRONTIERS IN ENDOCRINOLOGY 2022
Amphetamine modulation of long-term object recognition memory in rats: influence of stress FRONTIERS IN PHARMACOLOGY 2021
Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer CANCERS 2021
The two-faced role of sirt6 in cancer CANCERS 2021
Sirtuins Encyclopedia of Molecular Pharmacology 2021
Histone-deacetylase 8 drives the immune response and the growth of glioma GLIA 2021
Sirt5 inhibition induces brown fat-like phenotype in 3t3-l1 preadipocytes CELLS 2021
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2021
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 JOURNAL OF MEDICINAL CHEMISTRY 2021
JQ1, inibitore delle proteine BET, riduce i fattori di virulenza e la patogenicità di Aspergillus fumigatus. 13° Congresso Nazionale della Società Italiana di Microbiologia Farmaceutica Obiettivi e Sfide della Microbiologia Moderna per la Difesa della Salute 2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders JOURNAL OF MEDICINAL CHEMISTRY 2021
Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein-protein interactions CHEMICAL COMMUNICATIONS 2021
Emerging Therapeutic Potential of SIRT6 Modulators JOURNAL OF MEDICINAL CHEMISTRY 2021
Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats NEUROSCIENCE 2021
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression GASTROENTEROLOGY 2021
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation CANCERS 2020
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation CHEMMEDCHEM 2020

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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