Antonello Mai


Titolo Pubblicato in Anno
Targeting histone acetylation/deacetylation in parasites: an update (2017–2020) CURRENT OPINION IN CHEMICAL BIOLOGY 2020
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni PLOS NEGLECTED TROPICAL DISEASES 2020
Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells MOLECULES 2020
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas FRONTIERS IN PHARMACOLOGY 2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth MOLECULAR ONCOLOGY 2020
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity CHEMMEDCHEM 2020
Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs) EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis CHEMMEDCHEM 2020
HAT inhibitors in cancer therapy Histone Modifications in Therapy 2020
Lysine Acetyltransferase Inhibitors From Natural Sources FRONTIERS IN PHARMACOLOGY 2020
Identification of novel quinazoline derivatives as potent antiplasmodial agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat JOURNAL OF PSYCHOPHARMACOLOGY 2019
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones JOURNAL OF MEDICINAL CHEMISTRY 2019
The emerging role of epigenetics in human autoimmune disorders CLINICAL EPIGENETICS 2019
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells CLINICAL EPIGENETICS 2019
Sirtuins as drug targets Epigenetic Drug Discovery 2019
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) Epigenetics and Regeneration 2019
Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats FRONTIERS IN MOLECULAR NEUROSCIENCE 2019
Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2) JOURNAL OF MEDICINAL CHEMISTRY 2019


  • PE5_18


  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.


drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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