Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
HAT inhibitors in cancer therapy Histone Modifications in Therapy 2020
Lysine Acetyltransferase Inhibitors From Natural Sources FRONTIERS IN PHARMACOLOGY 2020
Identification of novel quinazoline derivatives as potent antiplasmodial agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat JOURNAL OF PSYCHOPHARMACOLOGY 2019
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones JOURNAL OF MEDICINAL CHEMISTRY 2019
The emerging role of epigenetics in human autoimmune disorders CLINICAL EPIGENETICS 2019
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells CLINICAL EPIGENETICS 2019
Sirtuins as drug targets Epigenetic Drug Discovery 2019
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) Epigenetics and Regeneration 2019
Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats FRONTIERS IN MOLECULAR NEUROSCIENCE 2019
Enzymatic and biological characterization of novel sirtuin modulators against cancer INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2) JOURNAL OF MEDICINAL CHEMISTRY 2019
Epigenetic polypharmacology: a new frontier for epi-drug discovery MEDICINAL RESEARCH REVIEWS 2019
α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors ACS MEDICINAL CHEMISTRY LETTERS 2019
DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation The DNA, RNA, and Histone Methylomes 2019
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype CLINICAL EPIGENETICS 2019
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer CANCERS 2019
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis CLINICAL EPIGENETICS 2019
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells EUROPEAN JOURNAL OF PHARMACOLOGY 2019

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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