Antonello Mai


Titolo Pubblicato in Anno
Epigenetic polypharmacology: a new frontier for epi-drug discovery MEDICINAL RESEARCH REVIEWS 2019
α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors ACS MEDICINAL CHEMISTRY LETTERS 2019
DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation The DNA, RNA, and Histone Methylomes 2019
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype CLINICAL EPIGENETICS 2019
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer CANCERS 2019
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis CLINICAL EPIGENETICS 2019
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells EUROPEAN JOURNAL OF PHARMACOLOGY 2019
H19-dependent transcriptional regulation of β3 and β4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells SCIENTIFIC REPORTS 2019
Histone deacetylases contribute to excitotoxicity-triggered degeneration of retinal ganglion cells in vivo MOLECULAR NEUROBIOLOGY 2019
Statins and histone deacetylase inhibitors affect lamin A/C - histone deacetylase 2 interaction in human cells FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2019
Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer CURRENT OPINION IN CHEMICAL BIOLOGY 2019
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 2018
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors NATURE COMMUNICATIONS 2018
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer CLINICAL CANCER RESEARCH 2018
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 CLINICAL EPIGENETICS 2018
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal OPEN ACCESS SCIENTIFIC REPORTS 2018
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice NEUROSCIENCE 2018
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications FUTURE MEDICINAL CHEMISTRY 2018
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES 2018


  • PE5_18


  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.


drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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