Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 EXPERT OPINION ON THERAPEUTIC PATENTS 2020
From parp1 to tnks2 Inhibition: a structure-based approach ACS MEDICINAL CHEMISTRY LETTERS 2020
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation SCIENCE ADVANCES 2020
A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action REDOX BIOLOGY 2020
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene HUMAN GENETICS 2020
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization ACS CHEMICAL BIOLOGY 2020
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells ACS MEDICINAL CHEMISTRY LETTERS 2020
Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
The pan-sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line FRONTIERS IN ONCOLOGY 2020
Sirt4: a multifaceted enzyme at the crossroads of mitochondrial metabolism and cancer FRONTIERS IN ONCOLOGY 2020
Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats NEUROPSYCHOPHARMACOLOGY 2020
The innovative potential of statins in cancer: new targets for new therapies FRONTIERS IN CHEMISTRY 2020
Targeting histone acetylation/deacetylation in parasites: an update (2017–2020) CURRENT OPINION IN CHEMICAL BIOLOGY 2020
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni PLOS NEGLECTED TROPICAL DISEASES 2020
Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells MOLECULES 2020
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas FRONTIERS IN PHARMACOLOGY 2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth MOLECULAR ONCOLOGY 2020
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity CHEMMEDCHEM 2020
Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs) EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis CHEMMEDCHEM 2020

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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