Antonello Mai


Titolo Pubblicato in Anno
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation FUTURE MEDICINAL CHEMISTRY 2016
The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery CELL 2016
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. MEDCHEMCOMM 2015
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies ACS MEDICINAL CHEMISTRY LETTERS 2015
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells JOURNAL OF MEDICINAL CHEMISTRY 2015
SIRT5 regulation of ammonia-induced autophagy and mitophagy AUTOPHAGY 2015
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents ACS CHEMICAL BIOLOGY 2015
Emerging approaches for histone deacetylase inhibitor drug discovery EXPERT OPINION ON DRUG DISCOVERY 2015
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas CANCER RESEARCH 2015
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity EUROPEAN NEUROPSYCHOPHARMACOLOGY 2015
Targeting lysine deacetylases (KDACs) in parasites PLOS NEGLECTED TROPICAL DISEASES 2015
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib BIOCHEMICAL PHARMACOLOGY 2015
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach JOURNAL OF MEDICINAL CHEMISTRY 2015
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts ONCOTARGET 2015
Sirtuin function in aging heart and vessels JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015
New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors THE JOURNAL OF BIOLOGICAL CHEMISTRY 2015


  • PE5_18


  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.


drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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