Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells CELL DEATH & DISEASE 2018
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds THE CHEMICAL RECORD 2018
Application of Small Epigenetic Modulators in Pediatric Medulloblastoma FRONTIERS IN PEDIATRICS 2018
EZH2, HIF-1, and their inhibitors: An overview on pediatric cancers FRONTIERS IN PEDIATRICS 2018
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. BIOORGANIC & MEDICINAL CHEMISTRY 2017
Structural basis of sirtuin 6 activation by synthetic small molecules. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION 2017
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity JOURNAL OF MEDICINAL CHEMISTRY 2017
Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase CHEMMEDCHEM 2017
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
Essential oil extraction, chemical analysis and anti-candida activity of calamintha nepeta (L.) Savi subsp. glandulosa (Req.) ball-new approaches MOLECULES 2017
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy CLINICAL EPIGENETICS 2017
EZH2 inhibitors: a patent review (2014-2016) EXPERT OPINION ON THERAPEUTIC PATENTS 2017
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells ONCOTARGET 2017
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. JOURNAL OF MEDICINAL CHEMISTRY 2017
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. NATURE COMMUNICATIONS 2017
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice NEUROSCIENCE LETTERS 2017
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases INTERNATIONAL JOURNAL OF OBESITY 2017

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

Progetti di Ricerca

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