Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications FUTURE MEDICINAL CHEMISTRY 2018
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES 2018
Trends of LSD1 inhibitors in viral infections FUTURE MEDICINAL CHEMISTRY 2018
Combined HAT/EZH2 modulation leads to cancer-selective cell death ONCOTARGET 2018
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia ONCOTARGET 2018
Epigenetic metalloenzymes CURRENT MEDICINAL CHEMISTRY 2018
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers PSYCHOPHARMACOLOGY 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS AGING CELL 2018
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy MOLECULAR CANCER THERAPEUTICS 2018
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells CELL DEATH & DISEASE 2018
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds THE CHEMICAL RECORD 2018
Application of Small Epigenetic Modulators in Pediatric Medulloblastoma FRONTIERS IN PEDIATRICS 2018
EZH2, HIF-1, and their inhibitors: An overview on pediatric cancers FRONTIERS IN PEDIATRICS 2018
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. BIOORGANIC & MEDICINAL CHEMISTRY 2017
Structural basis of sirtuin 6 activation by synthetic small molecules. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION 2017
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity JOURNAL OF MEDICINAL CHEMISTRY 2017
Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase CHEMMEDCHEM 2017
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

Progetti di Ricerca

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