Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Statins and histone deacetylase inhibitors affect lamin A/C - histone deacetylase 2 interaction in human cells FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2019
Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer CURRENT OPINION IN CHEMICAL BIOLOGY 2019
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 2018
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors NATURE COMMUNICATIONS 2018
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer CLINICAL CANCER RESEARCH 2018
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 CLINICAL EPIGENETICS 2018
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal OPEN ACCESS SCIENTIFIC REPORTS 2018
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice NEUROSCIENCE 2018
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications FUTURE MEDICINAL CHEMISTRY 2018
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES 2018
Trends of LSD1 inhibitors in viral infections FUTURE MEDICINAL CHEMISTRY 2018
Combined HAT/EZH2 modulation leads to cancer-selective cell death ONCOTARGET 2018
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia ONCOTARGET 2018
Epigenetic metalloenzymes CURRENT MEDICINAL CHEMISTRY 2018
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers PSYCHOPHARMACOLOGY 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS AGING CELL 2018
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy MOLECULAR CANCER THERAPEUTICS 2018
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells CELL DEATH & DISEASE 2018
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds THE CHEMICAL RECORD 2018
Application of Small Epigenetic Modulators in Pediatric Medulloblastoma FRONTIERS IN PEDIATRICS 2018

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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