Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
EZH2 inhibitors: a patent review (2014-2016) EXPERT OPINION ON THERAPEUTIC PATENTS 2017
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells ONCOTARGET 2017
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. JOURNAL OF MEDICINAL CHEMISTRY 2017
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. NATURE COMMUNICATIONS 2017
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice NEUROSCIENCE LETTERS 2017
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases INTERNATIONAL JOURNAL OF OBESITY 2017
Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma SCIENTIFIC REPORTS 2017
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model AUTOIMMUNITY 2016
Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent JOURNAL OF MEDICINAL CHEMISTRY 2016
LSD1 inhibitors: a patent review (2010-2015) EXPERT OPINION ON THERAPEUTIC PATENTS 2016
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2016
DNA methyltransferases Inhibitors from natural sources CURRENT TOPICS IN MEDICINAL CHEMISTRY 2016
Progress in the development of lysine methyltransferase SETD8 inhibitors CHEMMEDCHEM 2016
Sirtuin functions and modulation: from chemistry to the clinic CLINICAL EPIGENETICS 2016
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells AMERICAN JOURNAL OF CANCER RESEARCH 2016
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells ONCOTARGET 2016
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases BIOCHEMICAL PHARMACOLOGY 2016
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features SCIENCE ADVANCES 2016

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

Progetti di Ricerca

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