Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells JOURNAL OF MEDICINAL CHEMISTRY 2015
SIRT5 regulation of ammonia-induced autophagy and mitophagy AUTOPHAGY 2015
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents ACS CHEMICAL BIOLOGY 2015
Emerging approaches for histone deacetylase inhibitor drug discovery EXPERT OPINION ON DRUG DISCOVERY 2015
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas CANCER RESEARCH 2015
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity EUROPEAN NEUROPSYCHOPHARMACOLOGY 2015
Targeting lysine deacetylases (KDACs) in parasites PLOS NEGLECTED TROPICAL DISEASES 2015
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib BIOCHEMICAL PHARMACOLOGY 2015
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach JOURNAL OF MEDICINAL CHEMISTRY 2015
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts ONCOTARGET 2015
Sirtuin function in aging heart and vessels JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015
New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors THE JOURNAL OF BIOLOGICAL CHEMISTRY 2015
Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF CHEMMEDCHEM 2015

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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