Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE 2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2022
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription NUCLEIC ACIDS RESEARCH 2022
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity PHARMACEUTICALS 2022
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules THERANOSTICS 2022
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Sirtuin modulators: past, present, and future perspectives FUTURE MEDICINAL CHEMISTRY 2022
Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors EMBO REPORTS 2022
Current HDAC Inhibitors in Clinical Trials CHIMIA 2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni ACS INFECTIOUS DISEASES 2022
Amphetamine modulation of long-term object recognition memory in rats: influence of stress FRONTIERS IN PHARMACOLOGY 2021
Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer CANCERS 2021
The two-faced role of sirt6 in cancer CANCERS 2021
Sirtuins Encyclopedia of Molecular Pharmacology 2021
Histone-deacetylase 8 drives the immune response and the growth of glioma GLIA 2021
Sirt5 inhibition induces brown fat-like phenotype in 3t3-l1 preadipocytes CELLS 2021
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2021

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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