Antonello Mai

Pubblicazioni

Titolo Pubblicato in Anno
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2024
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process JOURNAL OF MEDICINAL CHEMISTRY 2024
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence JOURNAL OF MEDICINAL CHEMISTRY 2023
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey JOURNAL OF MEDICINAL CHEMISTRY 2023
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023
LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials FRONTIERS IN PHARMACOLOGY 2023
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design GREEN CHEMISTRY 2023
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery CELLS 2023
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection CELLS 2023
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation DRUG DISCOVERY TODAY 2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8 JOURNAL OF MEDICINAL CHEMISTRY 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors CURRENT OPINION IN STRUCTURAL BIOLOGY 2023
SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS ANTIOXIDANTS 2023
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa. MICROBIOLOGICAL RESEARCH 2023
The role of structural biology in the design of sirtuin activators CURRENT OPINION IN STRUCTURAL BIOLOGY 2023
Targeting ROS production through inhibition of NADPH oxidases NATURE CHEMICAL BIOLOGY 2023
State of the art of carbonic anhydrase activators FUTURE MEDICINAL CHEMISTRY 2023
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2023

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.

Keywords

drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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