Antonello Mai


Titolo Pubblicato in Anno
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence JOURNAL OF MEDICINAL CHEMISTRY 2023
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey JOURNAL OF MEDICINAL CHEMISTRY 2023
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023
LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials FRONTIERS IN PHARMACOLOGY 2023
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design GREEN CHEMISTRY 2023
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery CELLS 2023
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection CELLS 2023
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation DRUG DISCOVERY TODAY 2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8 JOURNAL OF MEDICINAL CHEMISTRY 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors CURRENT OPINION IN STRUCTURAL BIOLOGY 2023
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE 2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2022
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription NUCLEIC ACIDS RESEARCH 2022
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity PHARMACEUTICALS 2022
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules THERANOSTICS 2022


  • PE5_18


  • Life-science technologies & biotechnologies

Interessi di ricerca

Synthesis of new potential bio-active compounds, particularly in the field of

  1. epigenetics: inhibitors of HDACs (unselective and class-selective), HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs.
  2. anticancer agents.
  3. antiviral agents and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes
  4. antibacterial, antimycobacterial and antifungal agents.
  5. CNS agents
  6. Development of new methodology for the synthesis of heterocycles. Analysis and purification of organic mixtures. Study and characterization of organic molecules.


drug discovery
Epigenetic drugs
antiviral agents
Anticancer drugs
parasite growth inhibition

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