Pubblicazioni

ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression

2024 - AUTOPHAGY
Benedetti, Rossella; Romeo, Maria Anele; Arena, Andrea; Gilardini Montani, Maria Saveria; D'Orazi, Gabriella; Cirone, Mara

JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting c-Myc and mTOR despite the activation of prosurvival mechanisms

2023 - EXPERIMENTAL HEMATOLOGY
Arena, Andrea; Romeo, Maria Anele; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Cirone, Mara

The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells

2022 - BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Arena, A.; Romeo, M. A.; Benedetti, R.; Gilardini Montani, M. S.; Cirone, M.

Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemia

2022 - DRUG RESISTANCE UPDATES
Sniegocka, M.; Liccardo, F.; Fazi, F.; Masciarelli, S.

Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas

2022 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Benedetti, R.; Arena, A.; Romeo, M. A.; Gilardini Montani, M. S.; Gonnella, R.; Santarelli, R.; Trivedi, P.; Cirone, M.

Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise

2022 - CANCERS
D'Orazi, Gabriella; Cirone, Mara

Ire1 alpha/xbp1 axis sustains primary effusion lymphoma cell survival by promoting cytokine release and stat3 activation

2021 - BIOMEDICINES
Gonnella, R.; Gilardini Montani, M. S.; Guttieri, L.; Romeo, M. A.; Santarelli, R.; Cirone, M.

Er stress, upr activation and the inflammatory response to viral infection

2021 - VIRUSES
Cirone, M.

Role of upr sensor activation in cell death–survival decision of colon cancer cells stressed by dpe treatment

2021 - BIOMEDICINES
Benedetti, R.; Gilardini Montani, M. S.; Romeo, M. A.; Arena, A.; Santarelli, R.; D'orazi, G.; Cirone, M.

Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2

2021 - CELLS
Rinaldi, Roberta; Miglionico, Rocchina; Nigro, Ilaria; D’Orsi, Rosarita; Chiummiento, Lucia; Funicello, Maria; Lupattelli, Paolo; Laurenzana, Ilaria; Sgambato, Alessandro; Monné, Magnus; Bisaccia, Faustino; Francesca Armentano, Maria

Perturbation of bulk and selective macroautophagy, abnormal UPR activation and their interplay pave the way to immune dysfunction, cancerogenesis and neurodegeneration in ageing

2020 - AGEING RESEARCH REVIEWS
Cirone, M.

Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response

2020 - ONCOGENESIS
Giuli, Maria Valeria; Diluvio, Giulia; Giuliani, Eugenia; Franciosa, Giulia; Di Magno, Laura; Pignataro, Maria Gemma; Tottone, Luca; Nicoletti, Carmine; Besharat, Zein Mersini; Peruzzi, Giovanna; Pelullo, Maria; Palermo, Rocco; Canettieri, Gianluca; Talora, Claudio; d'Amati, Giulia; Bellavia, Diana; Screpanti, Isabella; Checquolo, Saula

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

2020 - CELLS
Romeo, M. A.; Santarelli, R.; Gilardini Montani, M. S.; Gonnella, R.; Benedetti, R.; Faggioni, A.; Cirone, M.

Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress

2019 - JOURNAL OF GENERAL VIROLOGY
Romeo, Maria Anele; Masuelli, Laura; Gaeta, Aurelia; Nazzari, Cristina; Granato, Marisa; GILARDINI MONTANI, MARIA SAVERIA; Faggioni, Alberto; Cirone, Mara

IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy

2018 - CELL DEATH DISCOVERY
Storniolo, Antonello; Alfano, Vincenzo; Carbotta, Sabino; Ferretti, Elisabetta; Di Renzo, Livia

Retinoic acid-induced differentiation sensitizes myeloid progenitors cells to ER stress

2017 - ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGYItalian Journal of Anatomy and Embryology
Masciarelli, Silvia; Capuano, Ernestina; Tiziana, Ottone; Mariadomenica, Divona; Simone De, Panfilis; Noguera, Nélida I.; Francesco, Lo coco; Fazi, Francesco

A novel role of c-FLIP protein in regulation of ER stress response

2016 - CELLULAR SIGNALLING
Conti, Silvia; Petrungaro, Simonetta; Marini, ELETTRA SARA; Masciarelli, Silvia; Tomaipitinca, Luana; Filippini, Antonio; Giampietri, Claudia; Ziparo, Elio

Quercetin affects Hsp70/IRE1alfa mediated protection from death induced by endoplasmic reticulum stress

2015 - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Storniolo, Antonello; Marisa, Raciti; Cucina, Alessandra; Bizzarri, Mariano; DI RENZO, Livia Maria

Cancer microenvironment and endoplasmic reticulum stress response

2015 - MEDIATORS OF INFLAMMATION
Giampietri, Claudia; Petrungaro, Simonetta; Conti, S; Facchiano, A; Filippini, Antonio; Ziparo, Elio

Downregulation of E2F1 during ER stress is required to induce apoptosis

2015 - JOURNAL OF CELL SCIENCE
Pagliarini, Vittoria; Giglio, Paola; Bernardoni, Paolo; De Zio, Daniela; FIMIA, Gian Maria; Piacentini, Mauro; Corazzari, Marco

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