Pubblicazioni

Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

2018 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Talapatra, Sandeep K.; Tham, Chuin Lean; Guglielmi, Paolo; Cirilli, Roberto; Chandrasekaran, Balakumar; Karpoormath, Rajshekhar; Carradori, Simone; Kozielski, Frank

Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors

2018 - BIOORGANIC CHEMISTRY

Cianni, Lorenzo; Sartori, Geraldo; Rosini, Fabiana; De Vita, Daniela; Pires, Gabriel; Lopes, Bianca Rebelo; LeitÃ£o, Andrei; Burtoloso, Antonio C B; Montanari, Carlos A

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae Î±- and Î²-class enzymes

2018 - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Bua, Silvia; Berrino, Emanuela; Del Prete, Sonia; Murthy, Vallabhaneni S; Vijayakumar, Vijayaparthasarathi; Tamboli, Yasinalli; Capasso, Clemente; Cerbai, Elisabetta; Mugelli, Alessandro; Carta, Fabrizio; Supuran, Claudiu T

Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: evaluation of antimicrobial, cytotoxic and hemolytic activities

2017 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Merlino, Francesco; Carotenuto, Alfonso; Casciaro, Bruno; Martora, Francesca; Loffredo, MARIA ROSA; DI GRAZIA, Antonio; Yousif, Ali M.; Brancaccio, Diego; Palomba, Luciana; Novellino, Ettore; Galdiero, Massimiliano; Iovene, Maria Rosaria; Mangoni, Maria Luisa; Grieco, Paolo

Natural modulators of nonalcoholic fatty liver disease: mode of action analysis and in silico ADME-Tox prediction

2017 - TOXICOLOGY AND APPLIED PHARMACOLOGY

Al Sharif, Merilin; Alov, Petko; Vitcheva, Vessela; Diukendjieva, Antonia; Mori, Mattia; Botta, Bruno; Tsakovska, Ivanka; Pajeva, Ilza

An update on structural insights into the enzymes of the polyamine-trypanothione pathway: Targets for new drugs against leishmaniasis

2017 - FUTURE MEDICINAL CHEMISTRY

Ilari, Andrea; Fiorillo, Annarita; Genovese, Ilaria; Colotti, Gianni

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the Î±3Î²4 nicotinic acetylcholine receptor subtype

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Matera, Carlo; Quadri, Marta; Sciaccaluga, Miriam; PomÃ¨, Diego Yuri; Fasoli, Francesca; De Amici, Marco; Fucile, Sergio; Gotti, Cecilia; Dallanoce, Clelia; Grazioso, Giovanni

Impulsivity is predicted by the thinness of the insular cortex in rats

2016 - MOLECULAR PSYCHIATRY

Belin Rauscent, A.; Daniel, M. L.; Puaud, M.; Jupp, B.; Sawiak, S.; Howett, D.; Mckenzie, C.; Caprioli, Daniele; Besson, M.; Robbins, T. W.; Everitt, B. J.; Dalley, J. W.; Belin, D.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drinkwater, Nyssa; Vinh, Natalie B.; Mistry, Shailesh N.; Bamert, Rebecca S.; Ruggeri, Chiara; Holleran, John P.; Loganathan, Sasdekumar; Paiardini, Alessandro; Charman, Susan A.; Powell, Andrew K.; Avery, Vicky M.; Mcgowan, Sheena; Scammells, Peter J.

Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids

2016 - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Carradori, Simone; Gidaro, Maria Concetta; Petzer, AnÃ©l; Costa, GiosuÃ¨; Guglielmi, Paolo; Chimenti, Paola; Alcaro, Stefano; Petzer, Jacobus P.

MmpL3 inhibitors: diverse chemical scaffolds inhibit the same target

2016 - MINI-REVIEWS IN MEDICINAL CHEMISTRY

Poce, Giovanna; Consalvi, Sara; Biava, Mariangela

Recreational use, analysis and toxicity of tryptamines

2015 - CURRENT NEUROPHARMACOLOGY

Tittarelli, Roberta; Mannocchi, Giulio; Pantano, Flaminia; Romolo, Francesco Saverio

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

2015 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Wapenaar, Hannah; van der Wouden, Petra E; Groves, Matthew R; Rotili, Dante; Mai, Antonello; Dekker, Frank J.

Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF

2015 - CHEMMEDCHEM

Castellano, Sabrina; Milite, Ciro; Feoli, Alessandra; Viviano, Monica; Mai, Antonello; Novellino, Ettore; Tosco, Alessandra; Sbardella, Gianluca

Green-synthesized silver nanoparticles as a novel control tool against dengue virus (DEN-2) and its primary vector Aedes aegypti

2015 - PARASITOLOGY RESEARCH

Sujitha, Vasu; Murugan, Kadarkarai; Paulpandi, Manickam; Panneerselvam, Chellasamy; Suresh, Udaiyan; Roni, Mathath; Nicoletti, Marcello; Higuchi, Akon; Madhiyazhagan, Pari; Subramaniam, Jayapal; Dinesh, Devakumar; Vadivalagan, Chithravel; Chandramohan, Balamurugan; Alarfaj, Abdullah A.; Munusamy, Murugan A.; Barnard, Donald R.; Benelli, Giovanni

Chemistry and pharmacology of a series of unichiral analogues of 2-(2-pyrrolidinyl)-1,4-benzodioxane, prolinol phenyl ether, and prolinol 3-pyridyl ether designed as Î±4Î²2-nicotinic acetylcholine receptor agonists

2015 - JOURNAL OF MEDICINAL CHEMISTRY

Bolchi, Cristiano; Valoti, Ermanno; Gotti, Cecilia; Fasoli, Francesca; Ruggeri, Paola; Fumagalli, Laura; Binda, Matteo; Mucchietto, Vanessa; Sciaccaluga, Miriam; Budriesi, Roberta; Fucile, Sergio; Pallavicini, Marco

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors

2015 - BIOORGANIC & MEDICINAL CHEMISTRY

Consalvi, Sara; Alfonso, Salvatore; Di Capua, Angela; Poce, Giovanna; Pirolli, Adele; Sabatino, Manuela; Ragno, Rino; Anzini, Maurizio; Sartini, Stefania; La Motta, Concettina; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Biava, Mariangela