Pubblicazioni

Fatty-acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models ofÂ amyloidosis

2025 - THE FEBS JOURNAL

Oddi, S.; Scipioni, L.; Totaro, A.; Giacovazzo, G.; Ciaramellano, F.; Tortolani, D.; Leuti, A.; Businaro, R.; Armeli, F.; Bilkei-Gorzo, A.; Coccurello, R.; Zimmer, A.; Maccarrone, M.

The Z isomer of pyridoxilidenerhodanine 5â²âphosphate is an efficient inhibitor of human pyridoxine 5â²âphosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target

2024 - THE FEBS JOURNAL

Graziani, Claudio; Barile, Anna; Antonelli, Lorenzo; Fiorillo, Annarita; Ilari, Andrea; Vetica, Fabrizio; di Salvo, Martino Luigi; Paiardini, Alessandro; Tramonti, Angela; Contestabile, Roberto

Macrophages and autophagy: partners in crime

2024 - THE FEBS JOURNAL

Vitaliti, Alessandra; Reggio, Alessio; Palma, Alessandro

Serine metabolism during differentiation of human iPSC-derived astrocytes

2023 - THE FEBS JOURNAL

Tripodi, Farida; Motta, Zoraide; Murtas, Giulia; Rabattoni, Valentina; Nonnis, Simona; Grassi Scalvini, Francesca; Rinaldi, Anna Maria; Rizzi, Roberto; Bearzi, Claudia; Badone, Beatrice; Sacchi, Silvia; Tedeschi, Gabriella; Maffioli, Elisa; Coccetti, Paola; Pollegioni, Loredano

Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli. A pivotal enzyme in the vitamin B6 salvage pathway

2023 - THE FEBS JOURNAL

Tramonti, Angela; Donkor, Akua K; Parroni, Alessia; Musayev, Faik N; Barile, Anna; Ghatge, Mohini S; Graziani, Claudio; Alkhairi, Mona; Alawadh, Mohammed; di Salvo, Martino Luigi; Safo, Martin K; Contestabile, Roberto

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

2022 - THE FEBS JOURNAL

Spizzichino, Sharon; Boi, Dalila; Boumis, Giovanna; Lucchi, Roberta; Liberati, Francesca Romana; Capelli, Davide; Montanari, Roberta; Pochetti, Giorgio; Piacentini, Roberta; Parisi, Giacomo; Paone, Alessio; Rinaldo, Serena; Contestabile, Roberto; Tramonti, Angela; Paiardini, Alessandro; Giardina, Giorgio; CutruzzolÃ , Francesca

Modifications of H3 K4methylation levels are associated with DNA hypermethylation in acute myeloid leukemia

2020 - THE FEBS JOURNAL

Scalea, Stefania; Maresca, Carmen; Catalanotto, Caterina; Marino, Rachele; Cogoni, Carlo; Reale, Anna; Zampieri, Michele; Zardo, Giuseppe

Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy

2020 - THE FEBS JOURNAL

Milazzo, Lisa; Exertier, CÃ©cile; Becucci, Maurizio; Freda, Ida; Montemiglio, Linda Celeste; Savino, Carmelinda; Vallone, Beatrice; Smulevich, Giulietta

Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation

2020 - THE FEBS JOURNAL

Nardella, C.; Barile, A.; di Salvo, M. L.; Milano, T.; Pascarella, S.; Tramonti, A.; Contestabile, R.

The molecular species responsible for Î±1-antitrypsin deficiency are suppressed by a small molecule chaperone

2020 - THE FEBS JOURNAL

Ronzoni, R.; Heyer-Chauhan, N.; Fra, A.; Pearce, A. C.; Rudiger, M.; Miranda, E.; Irving, J. A.; Lomas, D. A.

The anti-STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death

2020 - THE FEBS JOURNAL

Boriero, D.; Carcereri de Prati, A.; Antonini, L.; Ragno, R.; Sohji, K.; Mariotto, S.; Butturini, E.

R180T variant of Î´-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features

2019 - THE FEBS JOURNAL

Montioli, Riccardo; Paiardini, Alessandro; Giardina, Giorgio; Zanzoni, Serena; Cutruzzola, Francesca; Cellini, Barbara; Borri Voltattorni, Carla

Inhibition of pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide esculentin-1a(1-21)NH2

2019 - THE FEBS JOURNAL

Casciaro, Bruno; Lin, Qiao; Afonin, Sergii; Loffredo, Maria Rosa; de Turris, Valeria; Middel, Volker; Ulrich, Anne S; Di, Y Peter; Mangoni, Maria Luisa

Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2

2019 - THE FEBS JOURNAL

Visconti, L.; MalagrinÃ², F.; Gianni, S.; Toto, A.

Structural and functional investigation of the small ribosomal subunit biogenesis GTPase A (RsgA) from pseudomonasÂ aeruginosa

2019 - THE FEBS JOURNAL

Rocchio, S.; Santorelli, D.; Rinaldo, S.; Franceschini, M.; Malatesta, F.; Imperi, F.; Federici, L.; Travaglini-Allocatelli, C.; Di Matteo, A.

Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from PseudomonasÂ aeruginosa

2018 - THE FEBS JOURNAL

Mantoni, Federico; Paiardini, Alessandro; Brunotti, Paolo; D'Angelo, Cecilia; Cervoni, Laura; Paone, Alessio; Cappellacci, Loredana; Petrelli, Riccardo; Ricciutelli, Massimo; Leoni, Livia; Rampioni, Giordano; Arcovito, Alessandro; Rinaldo, Serena; CutruzzolÃ , Francesca; Giardina, Giorgio

The catalytic activity of serine hydroxymethyltransferase is essential for deÂ novo nuclear dTMP synthesis in lung cancer cells

2018 - THE FEBS JOURNAL

Giardina, Giorgio; Paone, Alessio; Tramonti, Angela; Lucchi, Roberta; Marani, Marina; Magnifico, Maria Chiara; Bouzidi, Amani; Pontecorvi, Valentino; Guiducci, Giulia; Zamparelli, Carlotta; Rinaldo, Serena; Paiardini, Alessandro; Contestabile, Roberto; CutruzzolÃ , Francesca

The MocR-like transcription factors: pyridoxal 5'-phosphate-dependent regulators of bacterial metabolism

2018 - THE FEBS JOURNAL

Tramonti, Angela; Nardella, Caterina; di Salvo, Martino L.; Pascarella, Stefano; Contestabile, Roberto

Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway

2017 - THE FEBS JOURNAL

Tramonti, Angela; Milano, Teresa; Nardella, Caterina; DI SALVO, Martino Luigi; Pascarella, Stefano; Contestabile, Roberto

Structure of the adenylation domain thr1 involved in the biosynthesis of 4-chlorothreonine in Streptomyces sp. OH-5093 - protein flexibility and molecular bases of substrate specificity

2017 - THE FEBS JOURNAL

Scaglione, Antonella; Fullone, Maria Rosaria; Montemiglio, Linda Celeste; Parisi, Giacomo; Zamparelli, Carlotta; Vallone, Beatrice; Savino, Carmelinda; Grgurina, Ingeborg

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization

2017 - THE FEBS JOURNAL

MIRANDA BANOS, MARIA ELENA; Ferrarotti, Ilaria; Berardelli, Romina; Laffranchi, Mattia; Cerea, Marta; Gangemi, Fabrizio; Haq, Imran; Ottaviani, Stefania; Lomas, David A.; Irving, James A.; Fra, Annamaria

Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions

2016 - THE FEBS JOURNAL

Gruet, Antoine; Dosnon, Marion; Blocquel, David; Brunel, Joanna; Gerlier, Denis; Das, Rahul K.; Bonetti, Daniela; Gianni, Stefano; Fuxreiter, Monika; Longhi, Sonia; Bignon, Christophe

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

2015 - THE FEBS JOURNAL

Giardina, Giorgio; Brunotti, Paolo; Fiascarelli, Alessio; Cicalini, A; Costa, Mg; Buckle, Am; Di Salvo, Martino Luigi; Giorgi, Alessandra; Marani, Marina; Paone, Alessio; Rinaldo, Serena; Paiardini, Alessandro; Contestabile, Roberto; Cutruzzola', Francesca

Molecular mechanism of pdxr - a transcriptional activator involved in the regulation of vitamin b biosynthesis in the probiotic bacterium Bacillus clausii

2015 - THE FEBS JOURNAL

Tramonti, Angela; Fiascarelli, Alessio; Milano, Teresa; Di Salvo, Martino Luigi; NoguÃ©s, Isabel; Pascarella, Stefano; Contestabile, Roberto

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

2015 - THE FEBS JOURNAL

Moriconi, Claudia; OrdoÃ±ez, Adriana; Lupo, Giuseppe; Gooptu, Bibek; Irving, James A; Noto, Rosina; Martorana, Vincenzo; Manno, Mauro; Timpano, Valentina; Guadagno, NOEMI ANTONELLA; Dalton, Lucy; Marciniak, Stefan J; Lomas, David A; MIRANDA BANOS, MARIA ELENA