Pubblicazioni

Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

2024 - SIGNAL TRANSDUCTION AND TARGETED THERAPY

Rampioni Vinciguerra, Gian Luca; Capece, Marina; Reggiani Bonetti, Luca; Nigita, Giovanni; Calore, Federica; Rentsch, Sydney; Magistri, Paolo; Ballarin, Roberto; Di Benedetto, Fabrizio; Distefano, Rosario; Cirombella, Roberto; Vecchione, Andrea; Belletti, Barbara; Baldassarre, Gustavo; Lovat, Francesca; Croce, Carlo M.

Role of autophagy in ischemic stroke: insights from animal models and preliminary evidence in the human disease

2024 - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Stanzione, Rosita; Pietrangelo, Donatella; Cotugno, Maria; Forte, Maurizio; Rubattu, Speranza

Autophagy Activation Associates with Suppression of Prion protein and Improved Mitochondrial Status in Glioblastoma Cells

2023 - CELLS

Lenzi, Paola; Busceti, Carla; Lazzeri, Gloria; Ferese, Rosangela; Biagioni, Francesca; Salvetti, Alessandra; Pompili, Elena; DE FRANCHIS, Valerio; Puglisi-Allegra, Stefano; Frati, Alessandro; Ferrucci, Michela; Fornai, Francesco

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

2023 - PHARMACEUTICS

Iranpanah, Amin; Kooshki, Leila; Zachariah Moradi, Seyed; Saso, Luciano; Fakhri, Sajad; Khan, Haroon

SMYD3 Modulates AMPK-mTOR Signaling Balance in Cancer Cell Response to DNA Damage

2023 - CELLS

Lepore Signorile, Martina; Sanese, Paola; Di Nicola, Elisabetta; Fasano, Candida; Forte, Giovanna; De Marco, Katia; Disciglio, Vittoria; Latrofa, Marialaura; Pantaleo, Antonino; Varchi, Greta; Del Rio, Alberto; Grossi, Valentina; Simone, Cristiano

3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells

2022 - PHARMACEUTICS

Santarelli, R.; Pompili, C.; Gilardini Montani, M. S.; Evangelista, L.; Gonnella, R.; Cirone, M.

The complex network of mTOR signalling in the heart

2022 - CARDIOVASCULAR RESEARCH

Sciarretta, S.; Forte, M.; Frati, G.; Sadoshima, J.

Treatment with the bacterial toxin CNF1 selectively rescues cognitive and brain mitochondrial deficits in a female mouse model of Rett syndrome carrying a MeCP2-null mutation

2021 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urbinati, C.; Cosentino, L.; Germinario, E. A. P.; Valenti, D.; Vigli, D.; Ricceri, L.; Laviola, G.; Fiorentini, C.; Vacca, R. A.; Fabbri, A.; De Filippis, B.

Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles

2021 - ALZHEIMER'S & DEMENTIA

Perluigi, M.; Picca, A.; Montanari, E.; Calvani, R.; Marini, F.; Matassa, R.; Tramutola, A.; Villani, A.; Familiari, G.; Domenico, F. D.; Butterfield, D. A.; Oh, K. J.; Marzetti, E.; Valentini, D.; Barone, E.

mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder

2021 - FREE RADICAL BIOLOGY & MEDICINE

Perluigi, M.; Di Domenico, F.; Barone, E.; Butterfield, D. A.

Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties

2021 - CELL DEATH & DISEASE

Luca, R.; Assenza, M. R.; Maiullari, F.; Pieroni, L.; Maiullari, S.; Federici, G.; Marini, F.; Rizzi, R.; Urbani, A.; Soddu, S.; Moretti, F.

Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimerâs dysmetabolism, neuropathology, and possible therapies

2021 - FREE RADICAL BIOLOGY & MEDICINE

Perluigi, M.; Di Domenico, F.; Butterfield, D. A.

Upfront treatment with mTOR inhibitor everolimus in pediatric low-grade gliomas: A single-center experience

2021 - INTERNATIONAL JOURNAL OF CANCER

Cacchione, Antonella; Lodi, Mariachiara; Carai, Andrea; Miele, Evelina; Tartaglia, Marco; Megaro, Giacomina; Del Baldo, Giada; Alessi, Iside; Colafati, Giovanna Stefania; Carboni, Alessia; Boccuto, Luigi; Diomedi Camassei, Francesca; Catanzaro, Giuseppina; Po, Agnese; Ferretti, Elisabetta; Pedace, Lucia; Pizzi, Simone; Folgiero, Valentina; Pezzullo, Marco; Corsetti, Tiziana; Secco, Domitilla Elena; Cefalo, Maria Giuseppina; Locatelli, Franco; Mastronuzzi, Angela

BVR-A deficiency leads to autophagy impairment through the dysregulation of AMPK/mTOR axis in the brainâImplications for neurodegeneration

2020 - ANTIOXIDANTS

Lanzillotta, C.; Zuliani, I.; Vasavda, C.; Snyder, S.; Paul, B.; Perluigi, M.; Di Domenico, F.; Barone, E.

Inhibition of phosphoinositide 3-kinase/protein kinase B signaling hampers the vasopressin-dependent stimulation of myogenic differentiation

2019 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sorrentino, S.; Barbiera, A.; Proietti, G.; Sica, G.; Adamo, S.; Scicchitano, B. M.

Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells

2019 - EUROPEAN JOURNAL OF PHARMACOLOGY

Sirotkin, A. V.; Adamcova, E.; Rotili, D.; Mai, A.; Mlyncek, M.; Mansour, L.; Alwasel, S.; Harrath, A. H.

Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma

2019 - MBIO

Caro-Vegas, Carolina; Bailey, Aubrey; Bigi, Rachele; Damania, Blossom; Dittmer, Dirk P

Role of mTOR signaling in tumor microenvironment. An overview

2018 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conciatori, Fabiana; Bazzichetto, Chiara; Pilotto, Sara; Bria, Emilio; COGNETTI, FRANCESCO; Falcone, I.; Cognetti, F.; Milella, M.; Ciuffreda, L.

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

2018 - TRANSLATIONAL NEURODEGENERATION

Tramutola, Antonella; Lanzillotta, Chiara; Barone, Eugenio; Arena, Andrea; Zuliani, Ilaria; Mosca, Luciana; Blarzino, Carla; Butterfield, D. Allan; Perluigi, Marzia; Di Domenico, Fabio

Oleuropein induces AMPK-dependent autophagy in NAFLD mice, regardless of the gender

2018 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Porcu, Cristiana; Sideri, Silvia; Martini, Maurizio; Cocomazzi, Alessandra; Galli, Andrea; Tarantino, Giovanni; Balsano, Clara.

mTOR in Down syndrome: Role in AÃ and tau neuropathology and transition to Alzheimer disease-like dementia

2018 - FREE RADICAL BIOLOGY & MEDICINE

Di Domenico, Fabio; Tramutola, Antonella; Foppoli, Cesira; Head, Elizabeth; Perluigi, Marzia; Butterfield, D. Allan

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

2017 - EXPERT REVIEW OF NEUROTHERAPEUTICS

Tramutola, Antonella; Lanzillotta, Chiara; DI DOMENICO, Fabio

The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics

2017 - ANTIOXIDANTS & REDOX SIGNALING

Di Domenico, Fabio; Barone, Eugenio; Perluigi, Marzia; Butterfield, D. Allan

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis

2017 - HEPATOLOGY

Liu, Pin; Ge, Mengmeng; Hu, Junjie; Li, Xiaolei; Che, Li; Sun, Kun; Cheng, Lili; Huang, Yuedong; Pilo, Maria G; Cigliano, Antonio; Pes, Giovanni M; Pascale, Rosa M; Brozzetti, Stefania; Vidili, Gianpaolo; Porcu, Alberto; Cossu, Antonio; Palmieri, Giuseppe; Sini, Maria C; Ribback, Silvia; Dombrowski, Frank; Tao, Junyan; Calvisi, Diego F; Chen, Ligong; Chen, Xin

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

2017 - CELL DISCOVERY

Pulito, Claudio; Mori, Federica; Sacconi, Andrea; Goeman, Frauke; Ferraiuolo, Maria; Pasanisi, Patrizia; Campagnoli, Carlo; Berrino, Franco; Fanciulli, Maurizio; Ford, Rebecca J.; Levrero, Massimo; Pediconi, Natalia; Ciuffreda, Ludovica; Milella, Michele; Steinberg, Gregory R.; Cioce, Mario; Muti, Paola; Strano, Sabrina; Blandino, Giovanni