Pubblicazioni

Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Stornaiuolo, M.; LA REGINA, Giuseppe; Passacantilli, Sara; Grassia, G.; Coluccia, Antonio; La Pietra, V.; Giustiniano, M.; Cassese, H.; Di Maro, S.; Brancaccio, D.; Taliani, S.; Ialenti, A.; Silvestri, Romano; Martini, C.; Novellino, E.; Marinelli, L.

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells

2015 - JOURNAL OF MEDICINAL CHEMISTRY
G., Di Pompo; M., Salerno; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; S., Avnet; G., Lattanzi; N., Baldini; Mai, Antonello

N‑substituted quinolinonyl diketo acid derivatives as HIV integrase strand transfer inhibitors and their activity against RNase H function of reverse transcriptase

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Pescatori, Luca; Metifiot, Mathieu; Chung, Suhman; Masoaka, Takashi; Crucitti Cuzzucoli, Giuliana; Messore, Antonella; Pupo, Giovanni; Madia, Valentina Noemi; Saccoliti, Francesco; Scipione, Luigi; Tortorella, Silvano; Di Leva, Francesco Saverio; Cosconati, Sandro; Marinelli, Luciana; Novellino, Ettore; Le Grice, Stuart F. J.; Pommier, Yves; Marchand, Christophe; Costi, Roberta; Di Santo, Roberto

Hydroxytyrosol-derived compounds: a basis for the creation of new pharmacological agents for cancer prevention and therapy

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Roberta, Bernini; Gilardini Montani, Maria Saveria; Nicolò, Merendino; Annalisa, Romani; Francesca, Velotti

Synthesis of triazole-linked analogues of c-di-gmp and their interactions with diguanylate cyclase

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Fernicola, Silvia; Torquati, Ilaria; Paiardini, Alessandro; Giardina, Giorgio; Rampioni, Giordano; Messina, Marco; Leoni, Livia; Del Bello, Fabio; Petrelli, Riccardo; Rinaldo, Serena; Cappellacci, Loredana; Cutruzzola', Francesca

Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors

2015 - JOURNAL OF MEDICINAL CHEMISTRY
LA REGINA, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Monti, Ludovica; Vullo, Daniela; Nuti, Elisa; Alterio, Vincenzo; De Simone, Giuseppina; Monti, Simona Maria; Pan, Peiwen; Parkkila, Seppo; Supuran, Claudiu T.; Rossello, Armando; Silvestri, Romano

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer

2015 - JOURNAL OF MEDICINAL CHEMISTRY
LA REGINA, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Verrico, Annalisa; Miele, Andrea; Monti, Ludovica; Nalli, Marianna; Alfonsi, Romina; DI MARCOTULLIO, Lucia; Gulino, Alberto; Ricci, Biancamaria; Soriani, Alessandra; Santoni, Angela; Caraglia, Michele; Porto, Stefania; Da Pozzo, Eleonora; Martini, Claudia; Brancale, Andrea; Marinelli, Luciana; Novellino, Ettore; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Milite, Ciro; Feoli, Alessandra; Sasaki, Kazuki; La Pietra, Valeria; Balzano, Amodio Luca; Marinelli, Luciana; Mai, Antonello; Novellino, Ettore; Castellano, Sabrina; Tosco, Alessandra; Sbardella, Gianluca

Structure−activity relationship of pyrrolyl diketo acid derivatives as dual Inhibitors of HIV‑1 integrase and reverse transcriptase ribonuclease H domain

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Cuzzucoli Crucitti, Giuliana; Métifiot, Mathieu; Pescatori, Luca; Messore, Antonella; Madia, Valentina Noemi; Pupo, Giovanni; Saccoliti, Francesco; Scipione, Luigi; Tortorella, Silvano; Esposito, Francesca; Corona, Angela; Cadeddu, Marta; Marchand, Christophe; Pommier, Yves; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto

Chemistry and pharmacology of a series of unichiral analogues of 2-(2-pyrrolidinyl)-1,4-benzodioxane, prolinol phenyl ether, and prolinol 3-pyridyl ether designed as α4β2-nicotinic acetylcholine receptor agonists

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Bolchi, Cristiano; Valoti, Ermanno; Gotti, Cecilia; Fasoli, Francesca; Ruggeri, Paola; Fumagalli, Laura; Binda, Matteo; Mucchietto, Vanessa; Sciaccaluga, Miriam; Budriesi, Roberta; Fucile, Sergio; Pallavicini, Marco

Distinct temporal fingerprint for cyclic adenosine monophosphate (cAMP) signaling of Indole-​2-​carboxamides as allosteric modulators of the cannabinoid receptors

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Cawston, Erin E.; Connor, Mark; Di Marzo, Vincenzo; Silvestri, Romano; Glass, Michelle

New frontiers in selective human MAO-​B inhibitors

2015 - JOURNAL OF MEDICINAL CHEMISTRY
Carradori, S; Silvestri, R.

Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma.

2015 - JOURNAL OF MEDICINAL CHEMISTRY
C., Tintori; Fallacara, ANNA LUCIA; M., Radi; C., Zamperini; E., Dreassi; E., Crespan; G., Maga; S., Schenone; F., Musumeci; C., Brullo; A., Richters; F., Gasparrini; A., Angelucci; C., Festuccia; S. D., Monache; D., Rauh; M., Botta

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