Pubblicazioni

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

2018 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Berardozzi, Simone; Bernardi, Flavia; Infante, Paola; Ingallina, Cinzia; Toscano, Sara; De Paolis, Elisa; Alfonsi, Romina; Caimano, Miriam; Botta, Bruno; Mori, Mattia; Di Marcotullio, Lucia; Ghirga, Francesca

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

2018 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Ortalli, M; Ilari, Andrea; Colotti, G; De Ionna, I; Battista, Theo; Bisi, A; Gobbi, S; Rampa, A; Di Martino RMC, ; Gentilomi, Ga; Varani, S; Belluti, F.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

2018 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Saccoliti, Francesco; Madia, VALENTINA NOEMI; Tudino, Valeria; DE LEO, Alessandro; Pescatori, Luca; Messore, Antonella; DE VITA, Daniela; Scipione, Luigi; Brun, Reto; Kaiser, Marcel; Mäser, Pascal; Magalhaes Calvet, Claudia; K Jennings, Gareth; M Podust, Larissa; Costi, Roberta; DI SANTO, Roberto

From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor

2017 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Bolchi, Cristiano; Bavo, Francesco; Gotti, Cecilia; Fumagalli, Laura; Fasoli, Francesca; Binda, Matteo; Mucchietto, Vanessa; Sciaccaluga, Miriam; Plutino, Simona; Fucile, Sergio; Pallavicini, Marco

Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells

2017 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Zwergel, Clemens; Czepukojc, Brigitte; Evain Bana, Emilie; Xu, Zhanjie; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Bagrel, Denise; Kirsch, Gilbert; Meiser, Peter; Jacob, Claus; Montenarh, Mathias; Valente, Sergio

Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: the case of trifluoroacetylation

2017 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Papastavrou, Nikolaos; Chatzopoulou, Maria; Ballekova, Jana; Cappiello, Mario; Moschini, Roberta; Balestri, Francesco; Patsilinakos, Alexandros; Ragno, Rino; Stefek, Milan; Nicolaou, Ioannis

Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: evaluation of antimicrobial, cytotoxic and hemolytic activities

2017 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Merlino, Francesco; Carotenuto, Alfonso; Casciaro, Bruno; Martora, Francesca; Loffredo, MARIA ROSA; DI GRAZIA, Antonio; Yousif, Ali M.; Brancaccio, Diego; Palomba, Luciana; Novellino, Ettore; Galdiero, Massimiliano; Iovene, Maria Rosaria; Mangoni, Maria Luisa; Grieco, Paolo

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Di Capua, Angela; Sticozzi, Claudia; Brogi, Simone; Brindisi, Margherita; Cappelli, Andrea; Sautebin, Lidia; Rossi, Antonietta; Pace, Simona; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Valacchi, Giuseppe; Giorgi, Gianluca; Giordani, Antonio; Poce, Giovanna; Biava, Mariangela; Anzini, Maurizio

(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Desideri, Nicoletta; PROIETTI MONACO, Luca; Fioravanti, Rossella; Biava, Mariangela; Yáñez, Matilde; Alcaro, Stefano; Ortuso, Francesco

VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Da Costa, Laurène; Roche, Manon; Scheers, Els; Coluccia, Antonio; Neyts, Johan; Terme, Thierry; Leyssen, Pieter; Silvestri, Romano; Vanelle, Patrice

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Matera, Carlo; Quadri, Marta; Sciaccaluga, Miriam; Pomè, Diego Yuri; Fasoli, Francesca; De Amici, Marco; Fucile, Sergio; Gotti, Cecilia; Dallanoce, Clelia; Grazioso, Giovanni

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

2016 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Drinkwater, Nyssa; Vinh, Natalie B.; Mistry, Shailesh N.; Bamert, Rebecca S.; Ruggeri, Chiara; Holleran, John P.; Loganathan, Sasdekumar; Paiardini, Alessandro; Charman, Susan A.; Powell, Andrew K.; Avery, Vicky M.; Mcgowan, Sheena; Scammells, Peter J.

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75

2015 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Cuzzucoli Crucitti, G.; Pescatori, Luca; Messore, A. A; Madia, VALENTINA NOEMI; Pupo, Giovanni; Saccoliti, Francesco; Scipione, Luigi; Tortorella, Silvano; Di Leva, F. S; Cosconati, S; Novellino, E; Debyser, Z; Christ, F; Costi, Roberta; DI SANTO, Roberto

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