Pubblicazioni

New Potent EV-A71 Antivirals Targeting Capsid.

2024 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Roux, Hugo; Touret, Franck; Coluccia, Antonio; Khoumeri, Omar; Majdi, Chaimae; Scio, Pietro; Silvestri, Romano; Vanelle, Patrice; Manon Roche, And

Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects

2024 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Culletta, Giulia; Buttari, Brigitta; Arese, Marzia; Brogi, Simone; Almerico, Anna Maria; Saso, Luciano; Tutone, Marco

Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization

2024 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Bonomini, Anna; Felicetti, Tommaso; Pacetti, Martina; Bertagnin, Chiara; Coletti, Alice; Giammarino, Federica; DE ANGELIS, Marta; Poggialini, Federica; Macchiarulo, Antonio; Sabatini, Stefano; Mercorelli, Beatrice; Nencioni, Lucia; Vicenti, Ilaria; Dreassi, Elena; Cecchetti, Violetta; Tabarrini, Oriana; Loregian, Arianna; Massari, Serena

Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity

2023 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Fioravanti, Rossella; Proia, Eleonora; Tyurenkov, Ivan N; Kurkin, Denis V; Bakulin, Dmitry A; Kovalev, Nikolay S; Sheikin, Dmitry S; Kirillov, Ivan A; Nawrozkij, Maxim B; Vernigora, Andrey A; Brunilina, Leila L; Fiorentino, Francesco; Mladenović, Milan; Rotili, Dante; Ragno, Rino

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo

2023 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Sebastiani, J.; Puxeddu, M.; Nalli, M.; Bai, R.; Altieri, L.; Rovella, P.; Gaudio, E.; Trisciuoglio, D.; Spriano, F.; Lavia, P.; Fionda, C.; Masci, D.; Urbani, A.; Bigogno, C.; Dondio, G.; Hamel, E.; Bertoni, F.; Silvestri, R.; La Regina, G.

Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Kurtanovic, N.; Tomasevic, N.; Matic, S.; Mitrovic, M. M.; Kostic, D. A.; Sabatino, M.; Antonini, L.; Ragno, R.; Mladenovic, M.

Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Menna, M.; Fiorentino, F.; Marrocco, B.; Lucidi, A.; Tomassi, S.; Cilli, D.; Romanenghi, M.; Cassandri, M.; Pomella, S.; Pezzella, M.; Del Bufalo, D.; Zeya Ansari, M. S.; Tomasevic, N.; Mladenovic, M.; Viviano, M.; Sbardella, G.; Rota, R.; Trisciuoglio, D.; Minucci, S.; Mattevi, A.; Rotili, D.; Mai, A.

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Ali, Wesam; Garbo, Sabrina; Kincses, Annamária; Nové, Márta; Spengler, Gabriella; Di Bello, Elisabetta; Honkisz-Orzechowska, Ewelina; Karcz, Tadeusz; Szymańska, Ewa; Żesławska, Ewa; Starek, Małgorzata; Dąbrowska, Monika; Nitek, Wojciech; Kucwaj-Brysz, Katarzyna; Pyka, Patryk; Fioravanti, Rossella; Jacob, Claus; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Daniele Parenti, Marco; Naldi, Marina; Manoni, Elisabetta; Fabini, Edoardo; Cederfelt, Daniela; Talibov, Vladimir O.; Gressani, Valeria; Guven, Ummu; Grossi, Valentina; Fasano, Candida; Sanese, Paola; DE MARCO, Katia; Shtil, Alexander A.; Kurkin, Alexander V.; Altieri, Andrea; Helena Danielson, U.; Caretti, Giuseppina; Simone, Cristiano; Varchi, Greta; Bartolini, Manuela; Del Rio, Alberto

Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Coluccia, Michele; Parisse, Valeria; Guglielmi, Paolo; Giannini, Giuseppe; Secci, Daniela

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Di Magno, L; Coluccia, A; Bufano, M; Ripa, S; La Regina, G; Nalli, M; Di Pastena, F; Canettieri, G; Silvestri, R; Frati, L

Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells

2022 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello

Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death

2021 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Zaiter, Jamila; Hibot, Achraf; Hafid, Abderrafia; Khouili, Mostafa; Neves, Claudia M. B.; Simões, Mário M. Q.; Neves, M. Graça P. M. S.; Faustino, M. Amparo F.; Dagci, Taner; Saso, Luciano; Armagan, Güliz

Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis

2021 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Consalvi, S.; Poce, G.; Ghelardini, C.; Di Cesare Mannelli, L.; Patrignani, P.; Bruno, A.; Anzini, M.; Calderone, V.; Martelli, A.; Testai, L.; Giordani, A.; Biava, M.

Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia

2021 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Bufano, M.; Nalli, M.; Sebastiani, J.; Brancaccio, D.; Da Pozzo, E.; Tremolanti, C.; Martini, C.; Orlando, V.; Biagioni, S.; Sinicropi, M. S.; Ceramella, J.; Iacopetta, D.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G.

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.

2021 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Vicenti, Ilaria; Grazia Martina, Maria; Boccuto, Adele; De Angelis, Marta; Giavarini, Giorgia; Dragoni, Filippo; Marchi, Serena; Maria Trombetta, Claudia; Crespan, Emmanuele; Maga, Giovanni; Eydoux, Cecilia; Decroly, Etienne; Montomoli, Emanuele; Nencioni, Lucia; Zazzi, Maurizio; Radi, Marco

6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis

2021 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Consalvi, S.; Venditti, G.; Zhu, J.; Boshoff, H. I.; Arora, K.; De Logu, A.; Ioerger, T. R.; Rubin, E. J.; Biava, M.; Poce, G.

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies

2020 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Nalli, M.; Mazzoccoli, C.; Da Pozzo, E.; Cavallini, C.; Martini, C.; Orlando, V.; Biagioni, S.; Mazzoni, C.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G.

New deferiprone derivatives as multi-functional cholinesterase inhibitors. Design, synthesis and in vitro evaluation

2020 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Bortolami, Martina; Pandolfi, Fabiana; De Vita, Daniela.; Carafa, Camilla; Messore, Antonella; DI SANTO, Roberto; Feroci, Marta; Costi, Roberta; Chiarotto, Isabella; Bagetta, Donatella; Alcaro, Stefano; Colone, Marisa; Stringaro, Annarita; Scipione, Luigi

Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma

2020 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Ali, Wesam; Spengler, Gabriella; Kincses, Annamária; Nové, Márta; Battistelli, Cecilia; Latacz, Gniewomir; Starek, Małgorzata; Dąbrowska, Monika; Honkisz-Orzechowska, Ewelina; Romanelli, Annalisa; Rasile, Manuela Monica; Szymańska, Ewa; Jacob, Claus; Zwergel, Clemens; Handzlik, Jadwiga

New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains

2020 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Nalli, M.; Armijos Rivera, J. I.; Masci, D.; Coluccia, A.; Badia, R.; Riveira-Muñoz, E.; Brambilla, A.; Cinquina, E.; Turriziani, O.; Falasca, F.; Catalano, M.; Limatola, C.; Esté, J. A.; Maga, G.; Silvestri, R.; Crespan, E.; La Regina, G.

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors

2020 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Guglielmi, Paolo; Mathew, Bijo; Secci, Daniela; Carradori, Simone

Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)

2020 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Tomaselli, D.; Mautone, N.; Mai, A.; Rotili, D.

Identification of novel quinazoline derivatives as potent antiplasmodial agents

2019 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Bouchut, A; Rotili, D; Pierrot, C; Valente, S; Lafitte, S; Schultz, J; Hoglund, U; Mazzone, R; Lucidi, A; Fabrizi, G; Pechalrieu, D; Arimondo, Pb; Skinner-Adams, Ts; Chua, Mj; Andrews, Kt; Mai, A; Khalife, J.

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells

2019 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Stazi, Giulia; Battistelli, Cecilia; Piano, Valentina; Mazzone, Roberta; Marrocco, Biagina; Marchese, Sara; Louie, Sharon M.; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Viviano, Monica; Sbardella, Gianluca; Ciogli, Alessia; Fabrizi, Giancarlo; Cirilli, Roberto; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Nomura, Daniel K.; Mattevi, Andrea; Mai, Antonello; Valente, Sergio

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